INT185186

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.59
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skeletal muscle 1
Pif (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 99.72 Very High Very High Very High
Chronic pancreatitis 28 99.70 Very High Very High Very High
Inflammation 6 99.52 Very High Very High Very High
imagery 4 63.88 Quite High
addiction 2 27.32 Quite Low
Spinal cord 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 30 99.70 Very High Very High Very High
INFLAMMATION 6 99.52 Very High Very High Very High
Stress 1 99.36 Very High Very High Very High
Cancer 102 98.44 Very High Very High Very High
Appetite Loss 23 95.12 Very High Very High Very High
Muscular Atrophy 10 93.16 High High
Weight Loss 8 93.16 High High
Body Weight 5 91.08 High High
Pancreatic Cancer 60 90.88 High High
Malignant Neoplastic Disease 30 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can be speculated, that the ongoing inflammation in patients with chronic pancreatitis is capable to generate PIF.
Positive_regulation (generate) of PIF associated with inflammation and chronic pancreatitis
1) Confidence 0.60 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.00 Pain Relevance 0.22
The central role in this process of – predominant – skeletal muscle waste seems to play the proteolysis-inducing factor (PIF) [4].
Positive_regulation (play) of PIF in skeletal muscle
2) Confidence 0.40 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 2.00 Pain Relevance 0.36
This pathway may be stimulated by a variety of tumor-induced agents, such as glucocorticoids, inflammatory cytokines, proteolysis-inducing factor (PIF), or oxidative stress [23].
Positive_regulation (inducing) of PIF associated with stress, inflammation, cancer and cytokine
3) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1950512 Disease Relevance 1.58 Pain Relevance 0.10

General Comments

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