INT185188

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2005
Last Reported 2005
Negated 4
Speculated 1
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 23.21
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
urine 5
muscle cells 1
Pif (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 17 99.84 Very High Very High Very High
Chronic pancreatitis 238 99.20 Very High Very High Very High
Inflammation 34 72.72 Quite High
imagery 34 61.96 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 510 100.00 Very High Very High Very High
Cancer 238 99.98 Very High Very High Very High
Appetite Loss 68 99.84 Very High Very High Very High
Malignant Neoplastic Disease 255 99.68 Very High Very High Very High
Gastrointestinal Neoplasms 34 99.32 Very High Very High Very High
Weight Loss 68 99.30 Very High Very High Very High
Pancreatitis 255 99.20 Very High Very High Very High
Body Weight 34 97.28 Very High Very High Very High
Disease 34 96.44 Very High Very High Very High
INFLAMMATION 34 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the majority of investigations found PIF expression only in tumour tissue, the expression of PIF in non-malignant tissue has been also reported [7].
Gene_expression (expression) of PIF associated with malignant neoplastic disease and cancer
1) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.10 Pain Relevance 0.20
PIF is expressed in a variety of gastrointestinal cancers [7].
Gene_expression (expressed) of PIF associated with gastrointestinal neoplasms
2) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.90 Pain Relevance 0.11
PIF was detected in two patients with CA19-9 negative pancreatic cancer, but was not detectable in 16 pancreatic cancer patients (15 of them with elevated CA19-9).
Neg (not) Gene_expression (detectable) of PIF associated with pancreatic cancer
3) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.23 Pain Relevance 0.21
Although the majority of investigations found PIF expression only in tumour tissue, the expression of PIF in non-malignant tissue has been also reported [7].
Gene_expression (expression) of PIF associated with malignant neoplastic disease and cancer
4) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.10 Pain Relevance 0.19
PIF was detected in two patients with CA19-9 negative pancreatic cancer, but was not detectable in 16 pancreatic cancer patients (15 of them with elevated CA19-9).
Gene_expression (detected) of PIF associated with pancreatic cancer
5) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.20 Pain Relevance 0.21
Interestingly, PIF expression was not dependent on cancer stage, but seemed to be a qualitative marker of pancreatic cancer: even stage 2 tumours expressed PIF in 83 per cent [8].
Gene_expression (expression) of PIF associated with cancer and pancreatic cancer
6) Confidence 0.77 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.75 Pain Relevance 0.07
Interestingly, PIF expression was not dependent on cancer stage, but seemed to be a qualitative marker of pancreatic cancer: even stage 2 tumours expressed PIF in 83 per cent [8].
Gene_expression (expressed) of PIF associated with cancer and pancreatic cancer
7) Confidence 0.67 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.65 Pain Relevance 0.08
We therefore hypothesized that PIF production in patients with a pancreatic tumour would clearly indicate the malignant nature of the disease.
Gene_expression (production) of PIF associated with malignant neoplastic disease, pancreatic cancer and disease
8) Confidence 0.60 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.55 Pain Relevance 0.09
Further investigations should clarify whether the onset of PIF expression in the long-term follow-up of chronic pancreatitis patients is associated with early malignancy and whether it precedes morphologic and clinical signs of pancreatic cancer.
Gene_expression (expression) of PIF associated with malignant neoplastic disease, pancreatic cancer and chronic pancreatitis
9) Confidence 0.60 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.13 Pain Relevance 0.17
PIF is a 24-kDa sulphated glycoprotein synthesized by cachexia-inducing murine and human tumours, which induces catabolism of myofibrillar proteins in skeletal muscle via a direct stimulation of the proteasome pathway in muscle cells [5].
Gene_expression (synthesized) of PIF in muscle cells associated with appetite loss and cancer
10) Confidence 0.60 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.95 Pain Relevance 0.35
Urine of patients with a pancreatic mass of uncertain malignancy was investigated for PIF expression by Western blot.
Spec (investigated) Gene_expression (expression) of PIF in Urine associated with malignant neoplastic disease
11) Confidence 0.60 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1184069 Disease Relevance 1.24 Pain Relevance 0.24
It was detected in the urine of 44 from 55 pancreatic cancer patients, who had a significantly greater total weight loss and rate of weight loss than patients whose urine did not contain PIF.
Neg (not) Gene_expression (contain) of PIF in urine associated with weight loss and pancreatic cancer
12) Confidence 0.58 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.79 Pain Relevance 0.06
The analysis of CA19-9 in dependence on the presence of PIF in urine in PIF negative patients revealed 22.5 U/l (SD: 742) and 580.5 U/l in PIF positive patients (SD: 25203) (p < 0.05).
Neg (negative) Gene_expression (negative) of PIF in urine associated with addiction
13) Confidence 0.58 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.16 Pain Relevance 0.22
The analysis of CA19-9 in dependence on the presence of PIF in urine in PIF negative patients revealed 22.5 U/l (SD: 742) and 580.5 U/l in PIF positive patients (SD: 25203) (p < 0.05).
Gene_expression (presence) of PIF in urine associated with addiction
14) Confidence 0.58 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.16 Pain Relevance 0.22
The analysis of CA19-9 in dependence on the presence of PIF in urine in PIF negative patients revealed 22.5 U/l (SD: 742) and 580.5 U/l in PIF positive patients (SD: 25203) (p < 0.05).
Gene_expression (positive) of PIF in urine associated with addiction
15) Confidence 0.58 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.18 Pain Relevance 0.21
A previous study in pancreatic cancer patients suggested PIF expression as a tumour marker, which is not related to tumour size.
Gene_expression (expression) of PIF associated with cancer and pancreatic cancer
16) Confidence 0.52 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1184069 Disease Relevance 1.08 Pain Relevance 0.15
PIF was detected in 6 patients with chronic pancreatitis without evidence for a malignancy by 12 months follow up or histology.
Neg (without) Gene_expression (detected) of PIF associated with malignant neoplastic disease and chronic pancreatitis
17) Confidence 0.52 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1184069 Disease Relevance 1.03 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox