INT18519

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0.14
Pain Relevance 8.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 4
hippocampus 4
substantia nigra 3
caudate-putamen 2
hypothalamus 1
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 24 100.00 Very High Very High Very High
Enkephalin 16 100.00 Very High Very High Very High
Morphine 12 99.98 Very High Very High Very High
Substantia nigra 4 98.60 Very High Very High Very High
Nucleus accumbens 2 98.44 Very High Very High Very High
tramadol 24 98.24 Very High Very High Very High
Hippocampus 13 98.04 Very High Very High Very High
fluoxetine 6 97.92 Very High Very High Very High
cocaine 10 97.16 Very High Very High Very High
Central nervous system 11 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 1 75.28 Quite High
Disease 1 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While morphine caused a downregulation of prodynorphin mRNA levels in all investigated areas (hypothalamus, hippocampus, and striatum), tramadol did not cause any significant change in the striatum, and did not decrease prodynorphin biosynthesis in the hypothalamus and in the hippocampus, at nontoxic doses (10 and 20 mg/kg).
Spec (investigated) Positive_regulation (caused) of Spec (investigated) Negative_regulation (downregulation) of prodynorphin mRNA in hippocampus associated with tramadol, hippocampus and morphine
1) Confidence 0.47 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401159 Disease Relevance 0 Pain Relevance 1.57
DOI (7 mg/kg), administered for 9 days, induced a decrease of preprodynorphin mRNA levels in the caudate-putamen and the nucleus accumbens core and shell.
Positive_regulation (induced) of Negative_regulation (decrease) of preprodynorphin mRNA in caudate-putamen associated with nucleus accumbens
2) Confidence 0.46 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526047 Disease Relevance 0.08 Pain Relevance 0.91
Acute and intermittent cocaine administration elevated the prodynorphin mRNA expression in the dorsal striatum, consistent with previous reports, while the abstinent phase resulted in a significant reduction of prodynorphin mRNA levels in the ventrorostral striatum.
Positive_regulation (resulted) of Negative_regulation (reduction) of prodynorphin mRNA in striatum associated with cocaine
3) Confidence 0.26 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.76
AMPH administered one hour prior to sacrifice caused a dose-dependent depletion of prodynorphin peptides in both the striatum and substantia nigra.
Positive_regulation (caused) of Negative_regulation (depletion) of prodynorphin in substantia nigra associated with substantia nigra
4) Confidence 0.25 Published 1990 Journal Brain Res. Section Abstract Doc Link 1975215 Disease Relevance 0 Pain Relevance 0.77
Unilateral 6-OHDA lesion produced an elevation in striatal GAD67 and enkephalin mRNA levels and to a decrease in dynorphin mRNA levels.
Positive_regulation (elevation) of Negative_regulation (decrease) of dynorphin associated with dynorphin and enkephalin
5) Confidence 0.19 Published 2002 Journal Synapse Section Abstract Doc Link 11954048 Disease Relevance 0.06 Pain Relevance 0.81
While morphine caused a downregulation of prodynorphin mRNA levels in all investigated areas (hypothalamus, hippocampus, and striatum), tramadol did not cause any significant change in the striatum, and did not decrease prodynorphin biosynthesis in the hypothalamus and in the hippocampus, at nontoxic doses (10 and 20 mg/kg).
Spec (investigated) Positive_regulation (caused) of in striatum Spec (investigated) Negative_regulation (downregulation) of prodynorphin mRNA in hippocampus associated with tramadol, hippocampus and morphine
6) Confidence 0.16 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401159 Disease Relevance 0 Pain Relevance 1.57
While morphine caused a downregulation of prodynorphin mRNA levels in all investigated areas (hypothalamus, hippocampus, and striatum), tramadol did not cause any significant change in the striatum, and did not decrease prodynorphin biosynthesis in the hypothalamus and in the hippocampus, at nontoxic doses (10 and 20 mg/kg).
Spec (investigated) Positive_regulation (caused) of in hypothalamus Spec (investigated) Negative_regulation (downregulation) of prodynorphin mRNA in hippocampus associated with tramadol, hippocampus and morphine
7) Confidence 0.16 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401159 Disease Relevance 0 Pain Relevance 1.57
AMPH administered one hour prior to sacrifice caused a dose-dependent depletion of prodynorphin peptides in both the striatum and substantia nigra.
Positive_regulation (caused) of in striatum Negative_regulation (depletion) of prodynorphin in substantia nigra associated with substantia nigra
8) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 1975215 Disease Relevance 0 Pain Relevance 0.77

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