INT185194

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.65
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DCD)
Anatomy Link Frequency
internal 3
urine 2
muscle 1
intestine 1
DCD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 87.92 High High
Chronic pancreatitis 14 83.76 Quite High
Multiple sclerosis 63 80.52 Quite High
Inflammatory response 12 77.04 Quite High
cytokine 47 75.40 Quite High
Inflammatory mediators 6 68.16 Quite High
nud 3 66.76 Quite High
Spinal cord 27 60.16 Quite High
antagonist 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 140 99.84 Very High Very High Very High
Cancer 90 99.82 Very High Very High Very High
Pancreatic Cancer 33 99.24 Very High Very High Very High
Malignant Neoplastic Disease 17 98.76 Very High Very High Very High
Carcinoma 4 98.16 Very High Very High Very High
Skin Cancer 2 96.60 Very High Very High Very High
Gastrointestinal Neoplasms 2 93.56 High High
Disease 44 91.56 High High
Multiple Sclerosis 168 90.88 High High
Weight Loss 18 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CHEC-9 is an internal fragment of the endogenous protein DSEP/Dermcidin/PIF [10-16].
Gene_expression (/) of PIF in internal
1) Confidence 0.65 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 1.05 Pain Relevance 0.28
CHEC-9 is an internal fragment of the endogenous protein DSEP/Dermcidin/PIF [10-16].
Gene_expression (/) of Dermcidin in internal
2) Confidence 0.65 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 1.05 Pain Relevance 0.28
CHEC-9 is an internal fragment of the endogenous protein DSEP/Dermcidin/PIF [10-16].
Gene_expression (/) of DSEP in internal
3) Confidence 0.65 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1592473 Disease Relevance 1.05 Pain Relevance 0.28
A tumor product, PIF is produced by cachexia-inducing murine and human tumors and initiates muscle protein degradation directly through activation of the proteasome pathway.
Gene_expression (produced) of PIF in muscle associated with appetite loss and cancer
4) Confidence 0.37 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.84 Pain Relevance 0
Tumor-derived PIF, a 24-kDa proteoglycan (35), is present in a broad spectrum of cancer patients (i.e. carcinomas of the breast, lung, ovary, melanoma, gastro intestine).
Gene_expression (present) of PIF in intestine associated with cancer, carcinoma and skin cancer
5) Confidence 0.31 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529387 Disease Relevance 1.39 Pain Relevance 0.10
Comparisons of urine PIF between the two groups were made using exact probabilities in a 2?
Gene_expression (Comparisons) of PIF in urine
6) Confidence 0.30 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529387 Disease Relevance 0.05 Pain Relevance 0
The presence of the proteolysis-inducing factor in urine does not predict the malignancy of a pancreatic tumour

Background

Gene_expression (presence) of proteolysis-inducing factor in urine associated with malignant neoplastic disease and pancreatic cancer
7) Confidence 0.06 Published 2005 Journal BMC Gastroenterol Section Title Doc Link PMC1184069 Disease Relevance 1.22 Pain Relevance 0.21

General Comments

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