INT18522

Context Info Confidence 0.67 First Reported 1986 Last Reported 2011 Negated 10 Speculated 4 Reported most in Abstract Documents 248 Total Number 253 Disease Relevance 160.85 Pain Relevance 44.87

Anatomy Link Frequency T cells 24 lung 22 natural killer cells 8 immune cells 6 poly 6 IFNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 3170 100.00 cytokine 3055 100.00 Inflammation 2276 100.00 Paracetamol 378 100.00 Multiple sclerosis 1823 99.92 anesthesia 37 99.76 depression 98 99.54 headache 65 99.52 Neuritis 12 99.30 Opioid 37 99.12

Disease Link Frequency Relevance Heat Cancer 5265 100.00 Rheumatoid Arthritis 3176 100.00 Infection 2824 100.00 INFLAMMATION 2438 100.00 Hepatitis C Virus Infection 1426 100.00 Apoptosis 1375 100.00 Skin Cancer 427 100.00 Opiate Addiction 316 100.00 Necrosis 287 100.00 Cold Sores 1601 99.98

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Via interaction with Toll-like receptor 7 on immune cells, imiquimod induces local production of cytokines, such as interferon (IFN)-alpha.

Positive_regulation (induces) of Gene_expression (production) of IFN in immune cells associated with cytokine

1) Confidence 0.67 Published 2004 Journal Clin. Cancer Res. Section Abstract Doc Link 15297396 Disease Relevance 0.17 Pain Relevance 0.12

Meclomen at nontoxic levels (10(-5) to 10(-8) mol/l) caused a 2-6 fold increase in interferon (IFN) production in lymphocytes induced by Sendai virus.

Positive_regulation (increase) of Gene_expression (production) of IFN in lymphocytes

2) Confidence 0.65 Published 1990 Journal Acta Virol. Section Abstract Doc Link 1975722 Disease Relevance 0.17 Pain Relevance 0.18

Although the majority of cell preparations tested exhibited an enhanced production of IFN in response to these opioid peptides, some did not.

Positive_regulation (enhanced) of Gene_expression (production) of IFN associated with opioid

3) Confidence 0.59 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 1.08

[A case of hypothyroidism induced by interferon therapy for renal cell carcinoma].

Positive_regulation (therapy) of Gene_expression (therapy) of interferon associated with renal cancer and thyroid disease

4) Confidence 0.50 Published 2001 Journal Nippon Hinyokika Gakkai Zasshi Section Title Doc Link 11517570 Disease Relevance 0.84 Pain Relevance 0.09

PGE2 primes naive T cells in a dose-dependent fashion for production of high levels of IL-4, IL-10 and IL-13, and very low levels of IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and TNF-beta.

Positive_regulation (fashion) of Gene_expression (levels) of IFN in naive T cells associated with necrosis and cancer

5) Confidence 0.49 Published 1997 Journal Eur. J. Immunol. Section Abstract Doc Link 9464843 Disease Relevance 0.80 Pain Relevance 0.56

The mean interleukin (IL)-2 and IL-6 plasma levels were lower in the AP group than in the normal group, whereas the mean interferon (IFN)-gamma, IL-4, and tumor necrosis factor (TNF)-alpha levels were higher in the AP group.

Positive_regulation (higher) of Gene_expression (levels) of IFN in plasma associated with necrosis and cancer

6) Confidence 0.49 Published 2002 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 12066852 Disease Relevance 0.53 Pain Relevance 0.39

and presents an essential question: how may PPAR ligands modulate the overexpression of IFN-?

Positive_regulation (overexpression) of Gene_expression (overexpression) of IFN

7) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.78 Pain Relevance 0.29

If the cytokines present in the early rheumatoid lesion define the microenvironment which is required for RA pathology then, based upon current data from mice and humans, IFN-?

Positive_regulation (required) of Gene_expression (present) of IFN associated with rheumatoid arthritis and cytokine

8) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 1.68 Pain Relevance 0.76

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (soluble) of Gene_expression (synthesis) of IFN associated with necrosis, anesthesia and cancer

9) Confidence 0.49 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53

To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.

Positive_regulation (detect) of Gene_expression (expression) of IFN in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine

10) Confidence 0.49 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.12 Pain Relevance 1.00

in combination with escalating concentrations of IFN-?

Positive_regulation (concentrations) of Gene_expression (concentrations) of IFN

11) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.64 Pain Relevance 0.23

However, the number of IFN-g-producing CD3+ T-cells in untreated BD patients was elevated in comparison to both control groups (p = 0.05).

Positive_regulation (elevated) of Gene_expression (g-producing) of IFN in T-cells

12) Confidence 0.49 Published 2007 Journal Clin. Exp. Rheumatol. Section Body Doc Link 17949552 Disease Relevance 0.14 Pain Relevance 0

In order to determine whether IFN-?

Spec (determine) Positive_regulation (determine) of Spec (determine) Gene_expression (determine) of IFN

13) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.71 Pain Relevance 0.54

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (increase) of Gene_expression (synthesis) of IFN-alpha associated with necrosis, anesthesia and cancer

14) Confidence 0.49 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (soluble) of Gene_expression (synthesis) of IFN-alpha associated with necrosis, anesthesia and cancer

15) Confidence 0.49 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.52

We detected a significant anesthesia-associated increase of interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha, and soluble interleukin-2 receptor (sIL-2R) synthesis after stimulation with different mitogens while interleukin (IL)-1 beta and IL-6 protein did not change significantly.

Positive_regulation (increase) of Gene_expression (synthesis) of IFN associated with necrosis, anesthesia and cancer

16) Confidence 0.49 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143381 Disease Relevance 0.37 Pain Relevance 0.53

Cell loss rates of IFN-?

Positive_regulation (rates) of Gene_expression (rates) of IFN

17) Confidence 0.49 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.06 Pain Relevance 0.12

At 24 hr, a massive neutrophil recruitment and an induced expression of a wide spectrum of murine cytokine mRNA (i.e., interleukin [IL]-1 beta, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor [TNF]-alpha and interferon [IFN]-gamma) occurred in the huPBL-SCID mouse peritoneal cavity.

Positive_regulation (induced) of Gene_expression (expression) of IFN in peritoneal cavity associated with necrosis, cancer, severe combined immunodeficiency and cytokine

18) Confidence 0.49 Published 1995 Journal Transplantation Section Abstract Doc Link 8525526 Disease Relevance 0.71 Pain Relevance 0.13

High bacterial load is coupled to very high levels of IFN-?

Positive_regulation (coupled) of Gene_expression (levels) of IFN

19) Confidence 0.49 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.57 Pain Relevance 0.04

Meclomen at nontoxic levels (10(-5) to 10(-8) mol/l) caused a 2-6 fold increase in interferon (IFN) production in lymphocytes induced by Sendai virus.

Positive_regulation (increase) of Gene_expression (production) of interferon in lymphocytes

20) Confidence 0.47 Published 1990 Journal Acta Virol. Section Abstract Doc Link 1975722 Disease Relevance 0.17 Pain Relevance 0.18

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