INT185227

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 4
lungs 2
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 66.80 Quite High
cytokine 8 63.84 Quite High
Neuropeptide 4 50.00 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 61 99.44 Very High Very High Very High
Infection 67 98.84 Very High Very High Very High
Immunization 11 97.92 Very High Very High Very High
Respiratory Syncytial Virus 62 88.64 High High
Targeted Disruption 2 82.28 Quite High
Sprains And Strains 34 75.84 Quite High
Mastocytoma 1 70.64 Quite High
Skin Cancer 52 65.16 Quite High
Cancer 46 56.40 Quite High
Pox Virus Infection 23 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since both CD11c and CD80 are expressed widely on murine APC we asked whether the presence of CD11c on CD8+ T cells is due to expression by T cells rather than to membrane transfer from APC during T cell priming.
Spec (whether) Positive_regulation (due) of Spec (whether) Localization (presence) of CD8 in T cell
1) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.47 Pain Relevance 0
Purified murine or human CD8+ and CD4+ T cells were stimulated three times per day for 2 days with either PBS or ?
Positive_regulation (stimulated) of Localization (murine) of CD8 in T cells
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813861 Disease Relevance 0.26 Pain Relevance 0.03
secreting CD8 T-cells can be detected only after 5 days in the lungs [35] whereas, after immunization with MVA-H1, they are present already in high frequencies before infection, and, upon infection, enter the lungs much more rapidly by relocation from other sites such as the spleen.
Positive_regulation (detected) of Localization (secreting) of CD8 in lungs associated with immunization and infection
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.03 Pain Relevance 0.03

General Comments

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