INT18524

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 5
Speculated 4
Reported most in Body
Documents 37
Total Number 41
Disease Relevance 18.79
Pain Relevance 7.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 4
Th1 cells 2
microglia 2
poly 2
A549 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 468 100.00 Very High Very High Very High
Inflammation 386 100.00 Very High Very High Very High
Central nervous system 40 100.00 Very High Very High Very High
Opioid 20 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
rheumatoid arthritis 381 99.80 Very High Very High Very High
cINOD 43 98.20 Very High Very High Very High
narcan 6 97.74 Very High Very High Very High
Spinal cord 10 96.44 Very High Very High Very High
Infliximab 78 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 425 100.00 Very High Very High Very High
Cancer 675 99.84 Very High Very High Very High
Rheumatoid Arthritis 383 99.80 Very High Very High Very High
Hypersensitivity 24 99.68 Very High Very High Very High
Disease 364 99.52 Very High Very High Very High
Apoptosis 147 99.40 Very High Very High Very High
Fever 26 98.64 Very High Very High Very High
Colitis 15 98.32 Very High Very High Very High
Myasthenia Gravis 2 97.88 Very High Very High Very High
Papillomavirus Infection 19 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and presents an essential question: how may PPAR ligands modulate the overexpression of IFN-?
Spec (may) Regulation (modulate) of Gene_expression (overexpression) of IFN
1) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.78 Pain Relevance 0.29
Until recently no randomized controlled trials of isoprinosine and interferon had been conducted.
Neg (no) Regulation (controlled) of Gene_expression (isoprinosine) of interferon
2) Confidence 0.41 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1343569 Disease Relevance 0.31 Pain Relevance 0.03
The PC-IFN soma is triangular or rounded and measures 16??
Regulation (triangular) of in triangular Gene_expression (soma) of PC-IFN in soma
3) Confidence 0.39 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC3006658 Disease Relevance 0.09 Pain Relevance 0.03
When 10(-8) M naloxone was included in cultures containing 10(-12) M beta-endorphin or Met-enkephalin no significant inhibition of the effect of either opioid on IFN production was observed.
Regulation (effect) of Gene_expression (production) of IFN associated with narcan, enkephalin and opioid
4) Confidence 0.38 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 1.06
The effect of the opioid peptides beta-endorphin and Met-enkephalin on interferon gamma (IFN) production by concanavalin A-stimulated human mononuclear cells was examined.
Regulation (effect) of Gene_expression (production) of IFN in mononuclear cells associated with enkephalin and opioid
5) Confidence 0.38 Published 1986 Journal Cell. Immunol. Section Abstract Doc Link 3026654 Disease Relevance 0 Pain Relevance 0.64
Effect of meclomen on production and action of human interferon alpha.
Regulation (Effect) of Gene_expression (production) of interferon
6) Confidence 0.37 Published 1990 Journal Acta Virol. Section Title Doc Link 1975722 Disease Relevance 0.17 Pain Relevance 0.19
Firstly, there is accumulating evidence that there is no or little difference between different types of IFN?
Neg (little) Regulation (difference) of Gene_expression (types) of IFN
7) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0.18 Pain Relevance 0
Results indicate that the ACTH levels and IFN-alpha gene expression were higher in the conditioned animals than in the controls.
Regulation (higher) of Gene_expression (expression) of IFN-alpha
8) Confidence 0.26 Published 1994 Journal Neuroimmunomodulation Section Abstract Doc Link 8528888 Disease Relevance 0 Pain Relevance 0.15
This explorative pilot study suggests a predictive value of baseline gene expression levels of IFN-induced genes.
Regulation (value) of Gene_expression (expression) of IFN
9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0.73 Pain Relevance 0.18
Hence, further studies in a large cohort of patients starting IFNß treatment are needed to validate and further investigate the predictive value of baseline IFN response gene expression levels and it is of great importance to find a correlation between clinical parameters and the biological IFN response.
Spec (investigate) Regulation (value) of Gene_expression (expression) of IFN
10) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0.38 Pain Relevance 0.07
Previously, we demonstrated significant differences in the expression of type I IFN-induced genes between untreated RRMS patients.[14] Here we investigated whether there is a relationship between the differential in vivo responsiveness to IFNß and baseline expression levels of IFN-induced genes.
Spec (whether) Regulation (responsiveness) of Gene_expression (expression) of IFN
11) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2271130 Disease Relevance 0 Pain Relevance 0
A highly upregulated gene in the IFN pathway, viperin, was overexpressed in A549 cells resulting in a significant reduction in viral replication.
Regulation (upregulated) of Gene_expression (overexpressed) of IFN in A549
12) Confidence 0.15 Published 2007 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2100376 Disease Relevance 1.23 Pain Relevance 0.05
The effect on absolute proportions of IFN-?
Regulation (effect) of Gene_expression (proportions) of IFN
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.38 Pain Relevance 0.21
The CXCL10 concentrations in the culture supernatants, therefore, despite the lower doses of IFN-?
Regulation (despite) of Gene_expression (doses) of IFN
14) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.14
Combination of 10-9 M naltrindole with deltrophin-I (10(-12)-10(-8)M) significantly inhibited the proliferative response but did not affect interferon production.
Neg (not) Regulation (affect) of Gene_expression (production) of interferon
15) Confidence 0.10 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9286627 Disease Relevance 0 Pain Relevance 0.27
To test the effects of IFN/STAT1 pathway expression levels on the apoptotic response to Dox we used three STAT1H cell lines (P3m2a, P2m3c, P3m5a) and three STAT1L cell lines (P2m3, P2m6b, and P2m5b).
Regulation (effects) of Gene_expression (expression) of IFN associated with apoptosis
16) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.60 Pain Relevance 0
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.
Regulation (regulates) of Gene_expression (production) of IFN associated with cytokine
17) Confidence 0.08 Published 1997 Journal Nature Section Title Doc Link 9121587 Disease Relevance 0.16 Pain Relevance 0.18
Here we report that clones of B16F1 tumors grown in the lungs of syngeneic C57BL/6 mice demonstrate variable transcriptional levels of IFN/STAT1 pathway expression.
Regulation (levels) of Gene_expression (expression) of IFN in lungs associated with cancer
18) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.87 Pain Relevance 0
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Regulation (calculation) of Gene_expression (expression) of IFN
19) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
These data indicate that the expression level of the IFN/STAT1 pathway affects the ability of B16F1 cells to colonize the lungs following IV injection.


Regulation (affects) of Gene_expression (expression) of IFN in lungs
20) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.22 Pain Relevance 0

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