INT185240

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.39
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
plugs 2
stem 2
brain 1
fibroblast 1
neural 1
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 62 98.16 Very High Very High Very High
medulla 30 94.56 High High
Hippocampus 27 86.64 High High
Spinal cord 105 83.04 Quite High
Lasting pain 4 62.52 Quite High
Multiple sclerosis 7 59.28 Quite High
cytokine 56 58.08 Quite High
metalloproteinase 33 48.52 Quite Low
withdrawal 20 48.48 Quite Low
Peripheral nervous system 12 19.56 Low Low
Disease Link Frequency Relevance Heat
Disease 216 99.68 Very High Very High Very High
Cold Sores 367 99.40 Very High Very High Very High
Amyloid Plaque 12 99.24 Very High Very High Very High
Lung Cancer 145 99.22 Very High Very High Very High
Alzheimer's Dementia 33 99.12 Very High Very High Very High
Epilepsy 7 93.92 High High
Convulsion 5 92.56 High High
Cancer 370 91.36 High High
Syndrome 8 90.72 High High
Lewis Lung Carcinoma 136 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to better understand the activation process occurring in astrocytes, we measured the colocalization between FGF-2 and GFAP after lesion by assessing FGF-2 intensity in both types of cells in each region of the CNS.
FGF-2 Binding (intensity) of in astrocytes associated with central nervous system
1) Confidence 0.37 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
A major target for FGF-2 is astrocytes, critical for the maintenance of neural homeostasis and for neuronal regeneration after brain damage (Ransom and Kettenmann, 1995).
FGF-2 Binding (target) of in neuronal
2) Confidence 0.35 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.14 Pain Relevance 0.10
It can interact with both fibroblast growth factor 2 (FGF2) and transforming growth factor beta (TGF?)
FGF2 Binding (interact) of in fibroblast
3) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.05 Pain Relevance 0
In contrast to previously described protocols, following buoyancy enrichment the neural precursor cells were maintained in a serum free environment with EGF and FGF2 as growth factors [9], [48].
FGF2 Binding (environment) of in precursor cells
4) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0.08
In addition, the cores of amyloid plaques were intensely stained with 4G8, and bFGF binding is co-localized with amyloid immunoreactivity as visualized by polyclonal antiserum to amyloid.
bFGF Binding (binding) of in plaques associated with alzheimer's dementia and amyloid plaque
5) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515433 Disease Relevance 0.82 Pain Relevance 0
The binding of bFGF in this mouse line is similar to that of AD cases in which bFGF binds specifically to A?
bFGF Binding (binds) of associated with disease
6) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515433 Disease Relevance 0.83 Pain Relevance 0
The binding of bFGF in this mouse line is similar to that of AD cases in which bFGF binds specifically to A?
bFGF Binding (binding) of associated with disease
7) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515433 Disease Relevance 0.82 Pain Relevance 0
Briefly, 7 days after 20 Gy local radiation of Swiss nude mice, two MG plug were (400 ┬Ál/plug) supplemented with FGF-2 (500 ng/ml) and Heparin (3 U/ml, Sigma Chemie, Buchs, Switzerland) and implanted within (dorsal) or outside (ventral) the irradiation area.
FGF-2 Binding (supplemented) of in plug
8) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0 Pain Relevance 0
For derivation from established neurospheres, derived from E14 foetal brain and maintained for 40 passages in EGF plus FGF-2, cultures were dissociated to single cells using Accutase (Sigma, St.
FGF-2 Binding (passages) of in brain
9) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04
Here we demonstrate that the complex neurosphere environment is dispensable for stem cell maintenance, and that the combination of fibroblast growth factor 2 (FGF-2) and epidermal growth factor (EGF) is sufficient for derivation and continuous expansion by symmetrical division of pure cultures of neural stem (NS) cells.
fibroblast growth factor 2 Binding (combination) of in stem
10) Confidence 0.21 Published 2005 Journal PLoS Biology Section Abstract Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Here we demonstrate that the complex neurosphere environment is dispensable for stem cell maintenance, and that the combination of fibroblast growth factor 2 (FGF-2) and epidermal growth factor (EGF) is sufficient for derivation and continuous expansion by symmetrical division of pure cultures of neural stem (NS) cells.
FGF-2 Binding (combination) of in stem
11) Confidence 0.21 Published 2005 Journal PLoS Biology Section Abstract Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
To confirm the in vitro results in an in vivo model, Matrigel plugs supplemented with PBS (controls), FGF-2, C5a, or C3a were implanted subcutaneously into mice.
FGF-2 Binding (implanted) of in plugs
12) Confidence 0.19 Published 2010 Journal Inflamm Res Section Body Doc Link PMC2902742 Disease Relevance 0.07 Pain Relevance 0
In the present study, a combination of bFGF and heparin recruited vessels from the surrounding tissues into the Matrigel.
bFGF Binding (combination) of in vessels
13) Confidence 0.15 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 1.52 Pain Relevance 0.03
Additional pro-angiogenic molecules and growth factors that are synthesized by MM cell lines and clinical specimens are interleukin-8 (IL-8) (Galffy, 1999; Davidson, 2004), bFGF (Strizzi, 2001b; Davidson, 2004), TGF-?
bFGF Binding (interleukin-8) of associated with lung cancer
14) Confidence 0.05 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.55 Pain Relevance 0
Paradiso and co-workers demonstrated that recombinant HSV-1-based vectors expressing a combination of two NTFs, fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF), increased survival and proliferation of freshly isolated neural progenitors and favoured their differentiation into neurons in vitro.
FGF-2 Binding (combination) of in neural associated with cold sores
15) Confidence 0.03 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.58 Pain Relevance 0.20

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