INT185243

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.91
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox1) DNA binding (Sox1)
Anatomy Link Frequency
neural 2
dorsal 1
Sox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 95.08 Very High Very High Very High
Hippocampus 47 79.60 Quite High
Dopamine 1 13.80 Low Low
Central nervous system 31 5.00 Very Low Very Low Very Low
withdrawal 24 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
bDMF 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Teratoma 72 97.24 Very High Very High Very High
Apoptosis 14 85.04 High High
Convulsion 44 69.52 Quite High
Disease 7 15.88 Low Low
Cancer 67 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low
Status Epilepticus 19 5.00 Very Low Very Low Very Low
Death 16 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 11 5.00 Very Low Very Low Very Low
Epilepsy 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells lack detectable expression of the pluripotency factors Oct4 and Nanog, and also of the early neural marker Sox1, but retain the pan-neuroepithelial marker Sox2 (Part r in Figure 2C).
Gene_expression (expression) of Sox1 in neural
1) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Notably, expression of Sox1-GFP (and endogenous Sox1) is lost during this process (Parts c and d in Figure 2A), but the cells remain positive for Sox2 and nestin.
Gene_expression (expression) of Sox1-GFP
2) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Notably, expression of Sox1-GFP (and endogenous Sox1) is lost during this process (Parts c and d in Figure 2A), but the cells remain positive for Sox2 and nestin.
Gene_expression (expression) of Sox1
3) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Absence of Sox1, but maintenance of Sox2, is a noteworthy feature of NS cells, in view of the postulated determinative function of these transcription factors [52].
Neg (Absence) Gene_expression (Absence) of Sox1
4) Confidence 0.47 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.05
The transplant population also expressed additional markers for neural precursors (Sox1) as well as anterior (Otx1) and ventral forebrain markers (Mash1, Nkx2.1) and dorsal markers (Pax7), demonstrating the presence of broad regional identities in these cultures (Figure S1D).


Gene_expression (expressed) of Sox1 in dorsal
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.07 Pain Relevance 0.07
Sorting of cells expressing the neural precursor marker Sox1 before transplantation has been shown to further reduce the risk of teratoma formation [10], [11].
Gene_expression (expressing) of Sox1 in neural associated with teratoma
6) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 0.84 Pain Relevance 0

General Comments

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