INT185244

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 4.71
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sox2) anatomical structure formation involved in morphogenesis (Sox2) nucleus (Sox2)
DNA binding (Sox2) transcription factor binding (Sox2) cytoplasm (Sox2)
Anatomy Link Frequency
stem cells 4
spikes 2
papillae 2
stem 2
embryos 1
Sox2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 113 95.16 Very High Very High Very High
antagonist 33 93.48 High High
Hippocampus 86 81.60 Quite High
tolerance 3 78.96 Quite High
Spinal cord 15 64.88 Quite High
Pyramidal cell 2 64.60 Quite High
imagery 146 57.68 Quite High
GABAergic 168 46.24 Quite Low
interneuron 32 33.16 Quite Low
projection neuron 4 16.20 Low Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 1 98.70 Very High Very High Very High
Cancer 239 98.68 Very High Very High Very High
Hypertrophy 244 98.40 Very High Very High Very High
Targeted Disruption 48 97.36 Very High Very High Very High
Teratoma 50 93.88 High High
Adhesions 9 92.56 High High
Glioblastoma 28 92.16 High High
Mesothelioma 79 90.80 High High
Recurrence 3 90.80 High High
Death 48 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding is backed up by several independent lines of evidence, including (1) decreased chance of hit, (2) increased chance of miss, (3) the prolonged latency of LCC-RyR coupling, and (4) the prolonged delay and progressive temporal dispersion of cell-wide Ca2+ spikes.
Gene_expression (coupling) of LCC in spikes
1) Confidence 0.65 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.34 Pain Relevance 0
This finding is backed up by several independent lines of evidence, including (1) decreased chance of hit, (2) increased chance of miss, (3) the prolonged latency of LCC-RyR coupling, and (4) the prolonged delay and progressive temporal dispersion of cell-wide Ca2+ spikes.
Gene_expression (spikes) of LCC in spikes
2) Confidence 0.65 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.35 Pain Relevance 0
Taken together, our data provide unequivocal evidence that LCC-RyR coupling undergoes a progressive failure during hypertrophy.
Gene_expression (coupling) of LCC associated with hypertrophy
3) Confidence 0.65 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1764437 Disease Relevance 0.75 Pain Relevance 0.07
Decreases in the expression levels of Pax6, Hes1, nestin, and Sox2 suggest that the immature RPCs had begun undergoing differentiation toward more mature states while co-cultured on the polymer scaffolds.
Gene_expression (expression) of Sox2
4) Confidence 0.57 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
-catenin signalling regulates Sox-2 expression [88].
Gene_expression (expression) of Sox-2
5) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.07 Pain Relevance 0.04
When Sox2 expression is reduce to 20% of normal levels fungiform placodes form, but papillae fail to develop to maturity.
Gene_expression (expression) of Sox2 in papillae
6) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.07 Pain Relevance 0.04
Overexpression of Sox2 increases fungiform papillae at the expense of filiform papillae development.
Gene_expression (Overexpression) of Sox2 in papillae
7) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.08 Pain Relevance 0.04
CSCs express stem cell-specific transcription factors such as Sox2 as well as other intracellular stem- and progenitor cell markers such as nestin, musashi, or aldehyde dehydrogenase [8].
Gene_expression (express) of Sox2 in stem
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004948 Disease Relevance 0.75 Pain Relevance 0.03
In contrast, the two populations differed drastically in their expression levels of Sox2 mRNA (Figure 10J), which may indicate a more stem cell-like status of the astroglia under neurosphere conditions and which may be the molecular correlate for their higher degree of plasticity.


Gene_expression (expression) of Sox2 mRNA in stem cell
9) Confidence 0.51 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.12 Pain Relevance 0.03
BLBP and Sox-2 are also expressed by proliferating cells in the SGZ [19].
Gene_expression (expressed) of Sox-2
10) Confidence 0.45 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
In contrast, astroglial cells cultured under neurosphere conditions expressed drastically higher levels of Sox2 mRNA compared to adherent astroglia (Figure 10J).
Gene_expression (levels) of Sox2 mRNA
11) Confidence 0.44 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.04
Given the high level of expression of Sox2 in neural stem cells [39], these data are in agreement with the observation that culturing postnatal astroglia from the cerebral cortex under neurosphere conditions leads to their de-differentiation towards a more stem cell-like state [33],[34].


Gene_expression (expression) of Sox2 in stem cells associated with cerebral cortex
12) Confidence 0.44 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.05
In contrast, astroglial cells cultured under neurosphere conditions expressed drastically higher levels of Sox2 mRNA compared to adherent astroglia (Figure 10J).
Gene_expression (expressed) of Sox2 mRNA
13) Confidence 0.44 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.04
Type 1 progenitors express nestin, glial fibrillary acidic protein (GFAP), brain lipid-binding protein, and sox2.
Gene_expression (express) of sox2 in brain
14) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.09 Pain Relevance 0.04
Dermal papilla cells, which endogenously express high levels of Sox2 and c-Myc, have been reported to be reprogrammed more efficiently than skin and embryonic fibroblasts [14].
Gene_expression (express) of Sox2 in fibroblasts
15) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
In our microarray analysis, we observed high expression of pluripotency-related genes involved in the core hESC regulatory circuitry, including OCT4, SOX2, and NANOG, as well as CRYPTO 1 and 3, LCK, and HESX1.
Gene_expression (expression) of SOX2
16) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.18 Pain Relevance 0
SOX2, another key pluripotency gene, is expressed at 7.4 times the level in hESCs as in EB [10].
Gene_expression (expressed) of SOX2
17) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.08 Pain Relevance 0
It has been previously shown that CD24 cells express Sox2 indicating they still retain stemness [28].
Gene_expression (express) of Sox2
18) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0 Pain Relevance 0
Similar expression levels were detected for c-Myc, Klf4, Sox2, p53 and p21 genes among the pGFs, mGFs and TTFs, although the expression levels of klf4, p53 and p21 in GFs were slightly higher than in TTFs at passage 6 (Fig. 5C).
Gene_expression (detected) of Sox2
19) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
GBs frequently overexpress genes typical of neural stem cells including Sox2 [106], Myc [27] and Oct4 [107].
Gene_expression (overexpress) of Sox2 in stem cells
20) Confidence 0.35 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.08 Pain Relevance 0

General Comments

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