INT185254

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 1.77
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pax6) nucleus (Pax6) intracellular (Pax6)
DNA binding (Pax6) cytoplasm (Pax6)
Anatomy Link Frequency
brain 2
ventricular zone 2
stem cells 2
neural 2
radial 1
Pax6 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 5 68.00 Quite High
Spinal cord 22 66.80 Quite High
Central nervous system 30 47.20 Quite Low
tetrodotoxin 12 24.08 Low Low
cytokine 40 23.64 Low Low
Action potential 26 15.48 Low Low
Inflammation 25 15.12 Low Low
chemokine 5 13.04 Low Low
Hippocampus 62 5.00 Very Low Very Low Very Low
cINOD 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 30 83.24 Quite High
Hydrocephalus 40 81.84 Quite High
Glioblastoma 20 77.92 Quite High
Schizophrenia 40 77.76 Quite High
Neurodegenerative Disease 65 74.96 Quite High
Sprains And Strains 70 71.32 Quite High
Congenital Anomalies 40 70.84 Quite High
Infection 85 59.44 Quite High
Cancer 22 58.32 Quite High
Reprotox - General 1 5 56.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The normal expression of Nfix in the ventricular zone of postnatal animals at this age (Figs. 7F &7G, 8F–H), together with the knowledge that ventricular zone progenitor cells express Pax6, strongly suggests that these cells are aberrant ventricular zone cells and may represent a hyperproliferation of these potential neural progenitor cells.
Gene_expression (express) of Pax6 in ventricular zone
1) Confidence 0.72 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.50 Pain Relevance 0
At P12–P16 (N = 3), Pax6 is highly expressed in both the normal ventricular zone cells in +/+ mice (Fig. 3C, +/+) and in the aberrant cells in the lateral ventricles of Nfix-/- mice (Fig. 3C, arrow -/-).
Gene_expression (expressed) of Pax6 in ventricular zone
2) Confidence 0.72 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0 Pain Relevance 0
While the nature and source of these cells is as yet unknown, it is intriguing that at P12–16 they express Pax6, a marker for neural progenitor cells [19,20].
Gene_expression (express) of Pax6 in neural
3) Confidence 0.72 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.44 Pain Relevance 0
RG are self-renewing stem cells that produce neurons and IPC, divide at the ventricular surface, and express PAX6, a homeodomain transcription factor.
Gene_expression (express) of PAX6 in stem cells
4) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.41 Pain Relevance 0
C) and BrdU and analyzed by flow cytometry for expression of TBR2 and PAX6.
Spec (analyzed) Gene_expression (expression) of PAX6
5) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0 Pain Relevance 0
The transition from RG to IPC occurs with a sequential increase in the expression of TBR2, followed by a reduction in PAX6 expression.
Gene_expression (expression) of PAX6
6) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.12 Pain Relevance 0.03
In this cascade, the PAX6 transcription factor is initially expressed by RG.
Gene_expression (expressed) of PAX6
7) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.19 Pain Relevance 0.03
C) on neural stem/progenitor cells (NPC) proliferation, we quantitated the intracellular expression of PAX6 and TBR2 in subtypes of NPC, radial glia (RG) cells and intermediate progenitor cells (IPC).
Gene_expression (expression) of PAX6 in radial
8) Confidence 0.59 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0 Pain Relevance 0
Decreases in the expression levels of Pax6, Hes1, nestin, and Sox2 suggest that the immature RPCs had begun undergoing differentiation toward more mature states while co-cultured on the polymer scaffolds.
Gene_expression (expression) of Pax6
9) Confidence 0.57 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
CEC generated the targeting vector and participated in mouse dissections, RNA preparation and manuscript production, Y-TY screened ES cells for targeted integration and did the initial sectioning of mouse brains, JSB participated in sectioning and staining of mouse brains, analysis of brain morphology, DCX immunohistochemistry and manuscript production, JMO performed maintenance and breeding of mice, mouse dissections, tissue and RNA isolation and QPCR analyses of gene expression and discovered that soft dough could rescue the lethality of Nfix-/- mice, CP discovered that the aberrant ventricular cells expressed Pax6, assessed NFIX expression in developing brain and aided in manuscript production, MP verified in multiple independent mice the expression of Pax6 in the aberrant ventricular cells, pH3 immunohistochemistry, and aided in manuscript production, EDL aided in generation of the NfixKO ES cells and manuscript preparation, LJR supervised CP and MP and participated in manuscript preparation, interpretation of NFIX expression patterns and experiment planning and RMG initiated and directed the overall project, designed the PCR primers for assessing targeted integration and genotype, directed Y-TY, participated in some mouse dissections and did most of the manuscript preparation.


Gene_expression (expressed) of Pax6 in brain
10) Confidence 0.56 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.06 Pain Relevance 0
CEC generated the targeting vector and participated in mouse dissections, RNA preparation and manuscript production, Y-TY screened ES cells for targeted integration and did the initial sectioning of mouse brains, JSB participated in sectioning and staining of mouse brains, analysis of brain morphology, DCX immunohistochemistry and manuscript production, JMO performed maintenance and breeding of mice, mouse dissections, tissue and RNA isolation and QPCR analyses of gene expression and discovered that soft dough could rescue the lethality of Nfix-/- mice, CP discovered that the aberrant ventricular cells expressed Pax6, assessed NFIX expression in developing brain and aided in manuscript production, MP verified in multiple independent mice the expression of Pax6 in the aberrant ventricular cells, pH3 immunohistochemistry, and aided in manuscript production, EDL aided in generation of the NfixKO ES cells and manuscript preparation, LJR supervised CP and MP and participated in manuscript preparation, interpretation of NFIX expression patterns and experiment planning and RMG initiated and directed the overall project, designed the PCR primers for assessing targeted integration and genotype, directed Y-TY, participated in some mouse dissections and did most of the manuscript preparation.


Gene_expression (expression) of Pax6 in brain
11) Confidence 0.56 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2414869 Disease Relevance 0.05 Pain Relevance 0
Meanwhile, expression of neural specific makers, e.g., PAX6 and SOX1, increased during differentiation (Figures 1C).
Gene_expression (expression) of PAX6 in neural
12) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
As a general neural stem cell marker and early neural transcription factor, PAX6 protein is detectable as early as day 6 of neural differentiation from hESC [16], [37].
Gene_expression (detectable) of PAX6 in stem cell
13) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Pax6
14) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Pax6
15) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Pax6
16) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
They express Pax6, Glast, and BLBP mRNAs (Figure 5A), and are immunopositive for nestin, RC2, vimentin, 3CB2, SSEA1/Lex1, Pax6, and prominin (Figures 5C, 5D, and S1).
Gene_expression (express) of Pax6
17) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Pax6 in ventral
18) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

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