INT185255

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sox2) anatomical structure formation involved in morphogenesis (Sox2) nucleus (Sox2)
DNA binding (Sox2) transcription factor binding (Sox2) cytoplasm (Sox2)
Anatomy Link Frequency
neural 1
Sox2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 99.04 Very High Very High Very High
Spinal cord 2 94.24 High High
cINOD 26 89.92 High High
antagonist 8 84.44 Quite High
Hippocampus 38 78.96 Quite High
Central nervous system 27 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 89 99.04 Very High Very High Very High
Neurodegenerative Disease 130 91.68 High High
Injury 14 62.80 Quite High
Gliosis 23 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Teratoma 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to this protocol, hGFs were first infected with a lentivirus to express the mouse Slc7a1 gene (by a plasmid vector from Addgene) and then infected with retroviruses coding human c-MYC, OCT3/4, SOX2 and KLF4 genes for iPS cell induction.


Positive_regulation (induction) of SOX2
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
Given the large increase in the number of Sox2-positive and nestin-positive cells and Dcx-positive migrating neuroblasts observed after KA, it seems that the anti-inflammatory actions of activin A in turn permit the proliferation of multipotent and self-renewing NSCs [21] and the subsequent proliferation and/or differentiation of neural precursor cells, which in turn lead to neurogenesis.
Positive_regulation (increase) of Sox2 in neural associated with inflammation and neurodegenerative disease
2) Confidence 0.18 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 1.22 Pain Relevance 0.37
Absence of Sox1, but maintenance of Sox2, is a noteworthy feature of NS cells, in view of the postulated determinative function of these transcription factors [52].
Positive_regulation (maintenance) of Sox2
3) Confidence 0.15 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.05

General Comments

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