INT185258

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2011
Negated 9
Speculated 0
Reported most in Body
Documents 33
Total Number 41
Disease Relevance 11.28
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pou5f1) nucleoplasm (Pou5f1) nucleus (Pou5f1)
DNA binding (Pou5f1) transcription factor binding (Pou5f1) cytoplasm (Pou5f1)
Anatomy Link Frequency
stem cell 8
brain 3
upper 3
blood 2
mesoderm 2
Pou5f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 14 99.06 Very High Very High Very High
antagonist 2 93.48 High High
Inflammatory mediators 14 93.32 High High
ischemia 106 85.76 High High
Action potential 66 79.28 Quite High
imagery 113 77.40 Quite High
anesthesia 27 17.28 Low Low
isoflurane 18 16.00 Low Low
Central nervous system 107 5.00 Very Low Very Low Very Low
neurotrophin 3 72 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 438 99.62 Very High Very High Very High
Cytomegalovirus Infection 504 99.42 Very High Very High Very High
Cancer 250 98.68 Very High Very High Very High
Obesity 126 97.34 Very High Very High Very High
Glioblastoma 18 94.40 High High
Teratoma 121 93.92 High High
INFLAMMATION 50 92.92 High High
Injury 132 92.76 High High
Tendinopathy 84 91.52 High High
Malignant Neoplastic Disease 15 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Gene_expression (expression) of Pou5f1
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
We have previously demonstrated that no expression of Nanog or Pou5f1 was detected following Nkx2-5(+) CPC derivation and extended culture in vitro.
Neg (no) Gene_expression (expression) of Pou5f1
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.37 Pain Relevance 0
No colonies of undifferentiated ESCs were detected as confirmed by the absence of Pou5f1 and Nanog expression.


Gene_expression (expression) of Pou5f1
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0.04
Oct4 expression must be closely regulated; too much or too little will actually induce differentiation [26].
Gene_expression (expression) of Oct4
4) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.06 Pain Relevance 0
and CD24(hi)CD29(+) cells, isolated from uninfected control brains, expressed Oct4 (Fig. 6, upper panel, histogram with blue line).
Gene_expression (expressed) of Oct4 in upper
5) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.15 Pain Relevance 0
To determine if CD24(hi) cells from the developing brain expressed Oct4, we performed intracellular staining for Oct4 as well as surface stained for CD15, CD24 and CD29 and analyzed these cell populations using flow cytometry.
Gene_expression (expressed) of Oct4 in brain
6) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.10 Pain Relevance 0
We then went on to determine if MCMV infection had any effect on Oct4 expression among this defined subset of cells.
Gene_expression (expression) of Oct4 associated with cytomegalovirus infection and infection
7) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.38 Pain Relevance 0
negative cells were found to express Oct4, it appeared that once CD29 expression occurred on these CD24(hi) cells the number of Oct4-expressing cells was reduced (Fig. 6, upper panel, histogram on the right).
Gene_expression (express) of Oct4 in upper
8) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.17 Pain Relevance 0
Data obtained from these experiments demonstrated that Oct4 expression was reduced in cells obtained from virus-infected brains compared to the cells from the brains of uninfected animals (upper panel, histogram overlays).


Gene_expression (expression) of Oct4 in brains
9) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.49 Pain Relevance 0
In our microarray analysis, we observed high expression of pluripotency-related genes involved in the core hESC regulatory circuitry, including OCT4, SOX2, and NANOG, as well as CRYPTO 1 and 3, LCK, and HESX1.
Gene_expression (expression) of OCT4
10) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.18 Pain Relevance 0
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Gene_expression (levels) of Pou5f1
11) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
Altered expression of the Oct4 transcription factor
Gene_expression (expression) of Oct4
12) Confidence 0.44 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.07 Pain Relevance 0
Reverse transcription polymerase chain reaction (RT-PCR) was used to compare the expression of embryonic markers (Oct4, NANOG, Rex1), cardiac transcription factors (Nkx2.5, MEF2C), ventricular specific proteins (?
Gene_expression (expression) of Oct4
13) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0
The pluripotency marker OCT3/4 (POU5F1) was not found to be expressed (Table 3).
Gene_expression (expressed) of POU5F1
14) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440803 Disease Relevance 1.21 Pain Relevance 0
NS cells do not express pluripotent cell-specific transcription factors Oct-4 and Nanog, but show appropriate expression of neural genes and absence of mesoderm and endoderm-specific genes.
Neg (not) Gene_expression (express) of Oct-4 in endoderm
15) Confidence 0.41 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.06 Pain Relevance 0
negative cells were found to express Oct4, it appeared that once CD29 expression occurred on these CD24(hi) cells the number of Oct4-expressing cells was reduced (Fig. 6, upper panel, histogram on the right).
Gene_expression (expressing) of Oct4 in upper
16) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.28 Pain Relevance 0
This neonatal brain infection was also associated with altered expression of Oct4, a multipotency marker; as well as down regulation of the neurotrophins BDNF and NT3, which are essential to regulate the birth and differentiation of neurons during normal brain development.
Gene_expression (expression) of Oct4 in brain associated with infection
17) Confidence 0.40 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.59 Pain Relevance 0
Expression of stem cell markers (Oct4, NANOG, Rex1) decreased substantially by day 28, while early stage cardiac transcriptional factors (Nkx2.5, MEF2C) appeared between days 14–28.
Gene_expression (Expression) of Oct4 in stem cell
18) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.09 Pain Relevance 0.12
These cells lack detectable expression of the pluripotency factors Oct4 and Nanog, and also of the early neural marker Sox1, but retain the pan-neuroepithelial marker Sox2 (Part r in Figure 2C).
Gene_expression (expression) of Oct4 in neural
19) Confidence 0.36 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
NS cells do not express pluripotent cell-specific transcription factors Oct-4 and Nanog, but show appropriate expression of neural genes and absence of mesoderm and endoderm-specific genes.
Neg (not) Gene_expression (express) of Oct-4 in endoderm
20) Confidence 0.35 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.06 Pain Relevance 0

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