INT185259

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sox1) DNA binding (Sox1)
Anatomy Link Frequency
neural 2
Sox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 5.00 Very Low Very Low Very Low
withdrawal 12 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
bDMF 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Teratoma 4 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, expression of Sox1-GFP (and endogenous Sox1) is lost during this process (Parts c and d in Figure 2A), but the cells remain positive for Sox2 and nestin.
Negative_regulation (lost) of Gene_expression (expression) of Sox1-GFP
1) Confidence 0.34 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
These cells lack detectable expression of the pluripotency factors Oct4 and Nanog, and also of the early neural marker Sox1, but retain the pan-neuroepithelial marker Sox2 (Part r in Figure 2C).
Negative_regulation (lack) of Gene_expression (expression) of Sox1 in neural
2) Confidence 0.34 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0

General Comments

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