INT185261

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 5.76
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (OLIG2) plasma membrane (OLIG2) nucleus (OLIG2)
DNA binding (OLIG2) cytoplasm (OLIG2)
Anatomy Link Frequency
motoneurons 4
nucleus 1
forebrain 1
oligodendrocyte 1
neural 1
OLIG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 10 95.36 Very High Very High Very High
Spinal cord 131 91.28 High High
Dopamine 18 78.80 Quite High
gABA 16 74.56 Quite High
unmyelinated 1 70.56 Quite High
Central nervous system 41 66.48 Quite High
midbrain 10 59.12 Quite High
Inflammation 1 34.24 Quite Low
anesthesia 6 26.52 Quite Low
Glutamate receptor 2 16.36 Low Low
Disease Link Frequency Relevance Heat
Oligodendroglioma 57 99.42 Very High Very High Very High
Rheumatoid Arthritis 54 99.24 Very High Very High Very High
Cancer 48 96.88 Very High Very High Very High
Vision Disorders 6 94.00 High High
Retina Disease 9 92.52 High High
Glioma 30 86.88 High High
Spinal Cord Injury 145 86.16 High High
Injury 88 71.28 Quite High
Neuroepithelial Neoplasms 3 63.72 Quite High
Contusions 9 58.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, OLIG2 is expressed in human OPC [45] and is necessary for specification and differentiation of human OPC [44].
Gene_expression (expressed) of OLIG2
1) Confidence 0.65 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.18 Pain Relevance 0.07
We determined that MP are able to mature and develop fundamental functions of normal motoneurons in vitro (expressing OLIG2, ISL1, and HOXC5), including directional growth of long axons, confirming the results from the previous study [11].
Gene_expression (expressing) of OLIG2 in motoneurons
2) Confidence 0.65 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.19 Pain Relevance 0.11
A ventralizing effect of RA was also observed by upregulation of OLIG2 expression, probably at the expense of IRX3, in agreement with previous findings suggesting that OLIG2 suppresses IRX3 [59] and interacts with progenitor homeodomain proteins, thus activating motor neuron differentiation pathway and HB9 gene.
Gene_expression (expression) of OLIG2 in motor neuron associated with rheumatoid arthritis
3) Confidence 0.64 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0.57 Pain Relevance 0.17
OLIGO-2 expression is relatively specific for oligodendrogliomas [8], and the combination of OLIGO-2 and GFAP expression provides further support for the diagnosis.
Gene_expression (expression) of OLIGO-2 associated with oligodendroglioma
4) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.48 Pain Relevance 0.05
OLIGO-2 expression is relatively specific for oligodendrogliomas [8], and the combination of OLIGO-2 and GFAP expression provides further support for the diagnosis.
Gene_expression (expression) of OLIGO-2 associated with oligodendroglioma
5) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.47 Pain Relevance 0.04
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Olig2
6) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
Double immunohistochemistry shows co-expression of Pax6/RC2, Olig2/RC2, Olig2/Pax6 (Figure 5C), and Pax6/Emx2 (Figure S1) in virtually every cell.
Gene_expression (expression) of Olig2
7) Confidence 0.61 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.03
Analyzing the transcription phenotype of obtained OPC at day 42, we observed strong expression of OLIG2 [42–44], which gives rise to motoneurons during the neurogenic phase.
Gene_expression (expression) of OLIG2 in motoneurons
8) Confidence 0.56 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2996083 Disease Relevance 0.19 Pain Relevance 0.04
To determine whether the neural progenitors have strictly rostral character we next examined the expression of caudal markers (Figures 4F and 4G) such as class I (IRX3, PAX6, PAX7) and class II (OLIG2, NKX2.2, NKX6.1), homeodomein proteins important for motoneuron differentiation [33], [34] and found them highly expressed at D7 and D42.
Spec (examined) Gene_expression (expression) of OLIG2 in motoneuron
9) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.23
The nucleus was positive for OLIGO-2 and the cytoplasm was positive for GFAP on immunohistochemical staining (Figure6, 7).
Gene_expression (positive) of OLIGO-2 in nucleus
10) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972288 Disease Relevance 1.46 Pain Relevance 0.05
All NS cells examined express the same panel of radial glia markers (Figures 5A and S2), plus the neural precursor markers Sox2, Sox3, and Emx2, and the bHLH (basic helix–loop helix) transcription factors Olig2 and Mash1 (Figure 5B).
Spec (examined) Gene_expression (express) of Olig2 in neural
11) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04
The presence of Olig2 and Mash1 is not characteristic of dorsal forebrain, and may reflect the ex vivo environment and a response to FGF-2.
Gene_expression (presence) of Olig2 in forebrain
12) Confidence 0.48 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04
Approximately 31% of hCNS-SCns remained nestin positive suggesting that they remain undifferentiated, however of the cells that differentiated the majority differentiated along the oligodendrocyte lineage expressing the immature Olig2 marker or the mature APC-CC1 marker (41%) and nearly as many differentiated into ß-tubulin III-positive neurons (38%).
Gene_expression (expressing) of Olig2 in oligodendrocyte
13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923623 Disease Relevance 0.23 Pain Relevance 0.04

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