INT185264

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.04
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ASCL1) DNA binding (ASCL1)
Anatomy Link Frequency
forebrain 1
neural 1
ASCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 3 91.12 High High
cva 50 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
withdrawal 12 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
bDMF 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 25 99.60 Very High Very High Very High
Neurodegenerative Disease 11 95.96 Very High Very High Very High
Cancer 58 89.00 High High
Thyroid Neoplasm 161 86.68 High High
Carcinoid 1 73.04 Quite High
Small Cell Lung Cancer 2 72.12 Quite High
Lung Cancer 1 71.88 Quite High
Reprotox - General 1 1 70.28 Quite High
Apoptosis 9 66.52 Quite High
Lymphatic System Cancer 1 61.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Mash1 [43], [44], Otx-2 [45] and Pax6 [46], other transcription factors crucial during the early phase of neurogenesis was demonstrated in control primary human MSCs and B10 cells, and expression levels of these transcription factors stayed steady after bFGF treatment.
Gene_expression (Expression) of Mash1 associated with neurodegenerative disease
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.24 Pain Relevance 0.05
These findings indicate that identification of compounds capable of pharmacologically activating the Notch1 signaling may have a therapeutic role in treating NE diseases caused by aberrant expression of ASCL1 and other hormones.
Gene_expression (expression) of ASCL1 associated with disease
2) Confidence 0.46 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.80 Pain Relevance 0
The presence of Olig2 and Mash1 is not characteristic of dorsal forebrain, and may reflect the ex vivo environment and a response to FGF-2.
Gene_expression (presence) of Mash1 in forebrain
3) Confidence 0.14 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04
All NS cells examined express the same panel of radial glia markers (Figures 5A and S2), plus the neural precursor markers Sox2, Sox3, and Emx2, and the bHLH (basic helix–loop helix) transcription factors Olig2 and Mash1 (Figure 5B).
Spec (examined) Gene_expression (express) of Mash1 in neural
4) Confidence 0.14 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0.04

General Comments

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