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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCND1, CDK4) cytoplasm (CCND1, CDK4) cytosol (CCND1, CDK4)
nucleus (CCND1, CDK4) cell division (CCND1, CDK4) intracellular (CCND1)
CCND1 (Homo sapiens)
CDK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 75.68 Quite High
Kinase C 1 75.04 Quite High
Taxol 2 30.08 Quite Low
Inflammation 38 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 95.80 Very High Very High Very High
Retinoblastoma 1 94.96 High High
Cancer 115 87.88 High High
Metastasis 10 85.08 High High
Congenital Anomalies 3 84.48 Quite High
Pancreatic Cancer 15 84.08 Quite High
Breast Cancer 69 83.88 Quite High
Apoptosis 125 76.96 Quite High
Malignant Neoplastic Disease 5 75.08 Quite High
Aggression 1 72.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p16 gene product binds to CDK4 and CDK6 inhibiting their interaction with cyclin D1.
cyclin D1 Binding (interaction) of CDK4
1) Confidence 0.13 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.87 Pain Relevance 0
Because cells begin to undergo cell division through mitogenic stimuli, there is induction of synthesis of cyclin D1, which is associated with the kinases CDK4 as well as CDK6.
cyclin D1 Binding (associated) of CDK4
2) Confidence 0.10 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.63 Pain Relevance 0.08
During G1 phase, the D-type cyclins (generally cyclin D1) are expressed in response to mitogenic signals, and by binding to CDK4 and CDK6, lead to activation of cyclin E/CDK2 and cyclin A/CDK2 in late G1 and S phase.
cyclin D1 Binding (binding) of CDK4
3) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Furthermore, association of the CDK4 with cyclin D1 can also be disrupted by the action of GSK3?
cyclin D1 Binding (association) of CDK4
4) Confidence 0.00 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.43 Pain Relevance 0

General Comments

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