INT185282

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 99.54 Very High Very High Very High
COX-2 inhibitor 52 40.52 Quite Low
antagonist 5 33.68 Quite Low
cINOD 17 8.72 Low Low
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 3 99.42 Very High Very High Very High
Small Cell Lung Cancer 63 99.12 Very High Very High Very High
Congenital Anomalies 2 94.08 High High
Cancer 199 88.04 High High
Pancreatic Cancer 16 77.56 Quite High
Lung Cancer 17 75.40 Quite High
Malignant Neoplastic Disease 4 68.56 Quite High
Aggression 2 65.84 Quite High
Glioma 2 54.72 Quite High
Skin Cancer 6 52.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies revealed that the treatment of human SCLC cells with capsaicin leads to differential recruitment of E2Fs on E2F-responsive promoters like cyclin E, TS, cdc25A and cdc6.
Localization (recruitment) of E2F associated with qutenza and small cell lung cancer
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.63 Pain Relevance 0.25
The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].
Localization (release) of E2F associated with retinoblastoma
2) Confidence 0.12 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.01 Pain Relevance 0
Retinoblastoma protein needs to be phosphorylated in order to release transcription factor E2F activating genes involved in the S phase-like PCNA (proliferating cell nuclear antigen) [82]. p53 is also important for the regulation of the G2/M transition, which requires activation of the cyclin B-cdk2 complex.
Localization (release) of E2F associated with retinoblastoma
3) Confidence 0.05 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.28 Pain Relevance 0

General Comments

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