INT185283

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.30
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
SAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 53.16 Quite High
agonist 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 99.54 Very High Very High Very High
Disorder Of Lipid Metabolism 16 98.80 Very High Very High Very High
Pancreatic Cancer 30 98.28 Very High Very High Very High
Pancreatic Ductal Carcinoma 4 97.36 Very High Very High Very High
Adenocarcinoma 16 92.56 High High
Hyperlipidemia 8 69.56 Quite High
Coronary Artery Disease 4 68.64 Quite High
Cardiovascular Disease 4 68.48 Quite High
Endometriosis (extended) 18 66.28 Quite High
Pancreatitis 4 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell cycle inhibitor and tumor suppressor gene p16 / MTS-1 has been reported to be altered in a variety of human tumors.
Regulation (altered) of MTS-1 associated with cancer
1) Confidence 0.14 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC1185532 Disease Relevance 0.53 Pain Relevance 0
Overall, our findings support the observations that p16 / MTS-1 gene alterations play a key role in dysregulated growth of pancreatic cancer and that methylation of the promoter is an important mechanism of its inactivation in Indian patients with pancreatic ductal adenocarcinoma.


Regulation (alterations) of MTS-1 associated with adenocarcinoma and pancreatic cancer
2) Confidence 0.14 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.67 Pain Relevance 0.05
Effects of dietary supplementation of SAI on lipoprotein profiles of the test rats are shown in Table 3.
Regulation (Effects) of SAI
3) Confidence 0.06 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2681466 Disease Relevance 0.54 Pain Relevance 0
Effects of SAI supplementation on liver antioxidative activities are shown in Table 4.
Regulation (Effects) of SAI in liver
4) Confidence 0.05 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2681466 Disease Relevance 0.56 Pain Relevance 0

General Comments

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