INT185284

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.79
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDK4) nucleoplasm (CDK4) signal transduction (CDK4)
nucleolus (CDK4) nucleus (CDK4) cell cycle (CDK4)
CDK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 75.04 Quite High
antagonist 6 74.88 Quite High
Taxol 2 30.08 Quite Low
Inflammation 65 5.00 Very Low Very Low Very Low
COX-2 inhibitor 52 5.00 Very Low Very Low Very Low
cytokine 29 5.00 Very Low Very Low Very Low
chemokine 19 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 7 99.04 Very High Very High Very High
Bone Cancer 6 98.28 Very High Very High Very High
Stress 9 95.80 Very High Very High Very High
Chromosome Aberrations 1 94.56 High High
Retinoblastoma 4 93.76 High High
Chondroblastoma 1 90.56 High High
Cancer 276 88.24 High High
Pancreatic Cancer 31 84.44 Quite High
Metastasis 17 84.28 Quite High
Chondrosarcoma 3 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p16 gene product binds to CDK4 and CDK6 inhibiting their interaction with cyclin D1.
CDK4 Binding (binds) of
1) Confidence 0.25 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.86 Pain Relevance 0
The p16 gene product binds to CDK4 and CDK6 inhibiting their interaction with cyclin D1.
CDK4 Neg (inhibiting) Binding (interaction) of
2) Confidence 0.25 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.87 Pain Relevance 0
During G1 phase, the D-type cyclins (generally cyclin D1) are expressed in response to mitogenic signals, and by binding to CDK4 and CDK6, lead to activation of cyclin E/CDK2 and cyclin A/CDK2 in late G1 and S phase.
CDK4 Binding (binding) of
3) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.12 Pain Relevance 0
Because cells begin to undergo cell division through mitogenic stimuli, there is induction of synthesis of cyclin D1, which is associated with the kinases CDK4 as well as CDK6.
CDK4 Binding (associated) of
4) Confidence 0.19 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.62 Pain Relevance 0.07
If phosphorylation occurs on T157 and T198 by PI3K (phosphoinositide 3-kinase), it triggers cell cycle transition by stabilizing the cyclin D1/cdk4 complex [55].
cdk4 Binding (complex) of
5) Confidence 0.16 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.78 Pain Relevance 0
For example, gain of chromosome 8q23 and CDK4 alone or together with MDM2 is associated with poor prognosis in osteosarcoma [34].
CDK4 Binding (associated) of associated with osteogenic sarcomas
6) Confidence 0.05 Published 2007 Journal Cytojournal Section Body Doc Link PMC1872031 Disease Relevance 1.11 Pain Relevance 0
Furthermore, association of the CDK4 with cyclin D1 can also be disrupted by the action of GSK3?
CDK4 Binding (association) of
7) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.43 Pain Relevance 0

General Comments

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