INT185287

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VHL) mitochondrion (VHL) cell morphogenesis (VHL)
endoplasmic reticulum (VHL) nucleus (VHL) extracellular matrix organization (VHL)
Anatomy Link Frequency
germline 1
VHL (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 141 100.00 Very High Very High Very High
Cancer 124 100.00 Very High Very High Very High
Disease 142 99.96 Very High Very High Very High
Pheochromocytoma 24 99.36 Very High Very High Very High
Congenital Anomalies 2 93.60 High High
Hemangioma 3 85.12 High High
Hemangioblastoma 6 84.44 Quite High
Skin Cancer 1 83.36 Quite High
Glioma 1 81.92 Quite High
Pancreatic Ductal Carcinoma 2 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A positive test result signals the presence of a VHL disease-causing
Transcription (presence) of VHL associated with disease
1) Confidence 0.60 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.59 Pain Relevance 0
is part of the VHL syndrome spectrum and may occur as the exclusive
Transcription (spectrum) of VHL associated with syndrome
2) Confidence 0.60 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.32 Pain Relevance 0
who do not have a detectable VHL germline mutation, somatic mosaicism
Neg (not) Transcription (have) of VHL in germline
3) Confidence 0.60 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.73 Pain Relevance 0
DNA hypermethylation can inhibit transcription of tumor suppressor genes and mismatch repair genes (p16, hMLH1 and VHL), providing an epigenetic mechanism of selection during tumorigenesis [11,12].
Transcription (transcription) of VHL associated with cancer
4) Confidence 0.52 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.13 Pain Relevance 0

General Comments

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