INT185288

Context Info Confidence 0.07 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.02 Pain Relevance 0

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2) transcription factor binding (E2F2)

E2F2 (Homo sapiens)

Pain Link Frequency Relevance Heat Chronic pancreatitis 1 5.00

Disease Link Frequency Relevance Heat Retinoblastoma 1 100.00 Congenital Anomalies 2 94.08 Cancer 31 83.44 Pancreatic Cancer 15 79.64 Malignant Neoplastic Disease 2 70.64 Aggression 1 67.92 Glioma 1 54.72 Skin Cancer 1 52.00 Adenocarcinoma 8 5.00 Pancreatitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].

Negative_regulation (prevents) of Localization (release) of E2F associated with retinoblastoma

1) Confidence 0.07 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.02 Pain Relevance 0

General Comments

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