INT185289

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 41.60 Quite Low
antagonist 6 34.76 Quite Low
cINOD 19 8.72 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 4 99.82 Very High Very High Very High
Congenital Anomalies 2 94.08 High High
Cancer 167 91.32 High High
Pancreatic Cancer 17 78.36 Quite High
Malignant Neoplastic Disease 4 69.36 Quite High
Aggression 2 66.64 Quite High
Glioma 1 54.72 Quite High
Skin Cancer 6 52.00 Quite High
Death 29 50.00 Quite Low
Injury 2 39.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].
Phosphorylation (phosphorylation) of E2F associated with retinoblastoma
1) Confidence 0.11 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.01 Pain Relevance 0
hypophosphorylated, and E2F remains bound to pRb [167].
Phosphorylation (hypophosphorylated) of E2F
2) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
Retinoblastoma protein needs to be phosphorylated in order to release transcription factor E2F activating genes involved in the S phase-like PCNA (proliferating cell nuclear antigen) [82]. p53 is also important for the regulation of the G2/M transition, which requires activation of the cyclin B-cdk2 complex.
Phosphorylation (phosphorylated) of E2F associated with retinoblastoma
3) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.28 Pain Relevance 0

General Comments

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