INT185307

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 12.14
Pain Relevance 6.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
macrophages 1
alveolar macrophages 1
lung 1
cortex 1
microglia 1


Pain Term Frequency Confidence Heat
Inflammation 385 100.00 Very High Very High Very High
B1 receptor 195 100.00 Very High Very High Very High
licofelone 39 99.56 Very High Very High Very High
cytokine 288 98.80 Very High Very High Very High
Osteoarthritis 153 98.40 Very High Very High Very High
spinal dorsal horn 24 98.32 Very High Very High Very High
Spinal cord 76 97.76 Very High Very High Very High
imagery 45 97.60 Very High Very High Very High
Inflammatory response 57 96.80 Very High Very High Very High
medulla 27 93.76 High High
Disease Term Frequency Confidence Heat
INFLAMMATION 455 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 52 99.52 Very High Very High Very High
Infection 99 99.28 Very High Very High Very High
Lung Injury 47 98.86 Very High Very High Very High
Osteoarthritis 161 98.40 Very High Very High Very High
Hypothermia 71 98.16 Very High Very High Very High
Fibrosis 8 97.36 Very High Very High Very High
Coronary Heart Disease 6 96.64 Very High Very High Very High
Injury 41 96.10 Very High Very High Very High
Encephalopathy 23 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 significantly induced the transcription of TNF and IL-1?
Transcription (transcription) of IL-1
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.28 Pain Relevance 0.33
In this study, we found that microglial activation in the cortex was associated with a significant increase of inflammatory gene transcription of Il-1?
Transcription (transcription) of Il-1 in cortex associated with inflammation
2) Confidence 0.69 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2553764 Disease Relevance 0.72 Pain Relevance 0.28
No significant difference (P>0.05) was noted in the mRNA levels of IL-1?
Transcription (levels) of IL-1
3) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518956 Disease Relevance 0.41 Pain Relevance 0.19
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Transcription (transcription) of IL-1 associated with inflammation
4) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.34 Pain Relevance 0.33
Effect of microglia inhibitors on mRNA levels of B1R, TRPV1, IL-1?
Transcription (levels) of IL-1 in microglia associated with b1 receptor
5) Confidence 0.69 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.61 Pain Relevance 0.71
To that end, we used SYBR Green real time RT-PCR and gene specific primers to measure the quantity of several mRNA transcripts, including IL-1?
Transcription (transcripts) of IL-1
6) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009713 Disease Relevance 0.18 Pain Relevance 0.19
Although several studies have shown that MI/R increases myocardial TNF concentrations, which contributes to irreversible tissue injury and myocardial dysfunction [2], Chong et al. reported that TNF mRNA expression was not increased after MI/R in wild type and C3H/HeJ mice compared to sham-operated mice, whereas myocardial mRNA expression of IL-1?
Transcription (expression) of IL-1 associated with injury and coronary heart disease
7) Confidence 0.69 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.53 Pain Relevance 0.21
Experiments have shown that licofelone can inhibit the mRNA expression of IL-1?
Transcription (expression) of IL-1 associated with licofelone
8) Confidence 0.69 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257437 Disease Relevance 0.59 Pain Relevance 0.65
-catenin transcriptional activity and that macrophages and IL-1?
Transcription (transcriptional) of IL-1 in macrophages
9) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0
In contrast, the expression level of IL-1?
Transcription (level) of IL-1
10) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.70 Pain Relevance 0.45
The more reduced redox potential of the Cys/CySS couple in SAA-supplemented mice is associated with a significant decrease in circulating and tissue levels of IL-1?
Transcription (levels) of IL-1
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.27 Pain Relevance 0.07
in response to oxidized Eh occurred due to increase in mRNA abundance, IL-1?
Transcription (abundance) of IL-1
12) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.07 Pain Relevance 0.03
After reverse transcription of mRNA (1 µg), the cDNA produced was analyzed for IL-6, IL-1?
Spec (analyzed) Transcription (analyzed) of IL-1
13) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.03
However, the increased mRNA level of TRPV1 in STZ was much less striking (3-fold) than that of B1R (27-fold), IL-1?
Transcription (level) of IL-1 associated with b1 receptor
14) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.52 Pain Relevance 0.89
As shown in Fig. 3, high fluid shear increases the mRNA levels of COX-2 and IL-1?
Transcription (levels) of IL-1
15) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.84 Pain Relevance 0.39
Initially, mRNA levels of a number of genes (CD14, IL-1?
Transcription (levels) of IL-1
16) Confidence 0.67 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2430192 Disease Relevance 0.63 Pain Relevance 0.08
, which might limit the examination of the inflammatory response in relation to fibrogenesis [42], and a semiquantitative histological index (PMI), our findings are in agreement with other experimental studies [43-45]. mRNA expression of IL-1?
Transcription (expression) of IL-1 associated with fibrosis and inflammatory response
17) Confidence 0.67 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.32 Pain Relevance 0.22
The present study was designed to obtain a methodological evaluation of the influence of chondroprotective agents on reference gene mRNA levels in the IL-1?
Transcription (levels) of IL-1
18) Confidence 0.67 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0
Hypothermia was associated with significantly (P < 0.05 versus normothermia) less upregulation of mRNA expression (IL-1?
Transcription (expression) of IL-1 associated with hypothermia
19) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 0.43 Pain Relevance 0.17
This data is consistent with the lower TLR2 expression levels found on alveolar macrophages in the current study and with data from a recent study in which lipoteichoic acid, a TLR2 ligand, was instilled experimentally into lung segments of human volunteers and resulted in a poor transcription of IL-1?
Transcription (transcription) of IL-1 in alveolar macrophages
20) Confidence 0.52 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.13 Pain Relevance 0.08

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