INT185315

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 8.65
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
diaphragm 1
liver 1
spleen 1
endometrium 1
kidney 1
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 108 100.00 Very High Very High Very High
cytokine 333 97.84 Very High Very High Very High
ischemia 18 97.48 Very High Very High Very High
cva 3 95.68 Very High Very High Very High
Inflammatory response 64 95.64 Very High Very High Very High
Inflammation 484 94.28 High High
Angina 16 93.36 High High
metalloproteinase 14 93.08 High High
Inflammatory mediators 23 87.60 High High
Pain 9 82.68 Quite High
Disease Link Frequency Relevance Heat
Burns 222 97.92 Very High Very High Very High
Cv Unclassified Under Development 15 97.48 Very High Very High Very High
Atherosclerosis 13 96.80 Very High Very High Very High
Injury 255 96.40 Very High Very High Very High
Hemorrhage 8 95.68 Very High Very High Very High
INFLAMMATION 549 95.28 Very High Very High Very High
Edema 2 94.72 High High
Pneumonia 7 94.28 High High
Depression 109 93.56 High High
Stable Angina Pectoris 10 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcription-generated cDNA encoding TLR2, TLR4, and TNF?
Transcription (transcription) of TLR4
1) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.14 Pain Relevance 0
In the present study, immuno-reactive TLR4 protein was detected in the stromal and epithelial cell compartments, in the endometrium of WT mice.
Transcription (detected) of TLR4 protein in endometrium
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.50 Pain Relevance 0.07
Interestingly, LPS stimulation increased the sTLR4 mRNA expression, suggesting a negative feedback to inhibit excessive cytokine production.
Transcription (expression) of TLR4 associated with cytokine
3) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.41 Pain Relevance 0.16
This study shows that the expression level of TLR4, serum levels of TNF-?
Transcription (level) of TLR4
4) Confidence 0.67 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.70 Pain Relevance 0.68
The present study has shown that mRNA and protein levels of TLR2 and TLR4 in circulating monocytes were higher in patients with AMI prior to PCI than in patients with SA and controls.
Transcription (levels) of TLR4 in monocytes
5) Confidence 0.66 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.04
After 24 h, mRNA levels of TLR-4 and the chemokine IL-8 were measured by real-time PCR.
Transcription (levels) of TLR-4 associated with chemokine
6) Confidence 0.66 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.51 Pain Relevance 0.23
It should be noted that CLP decreased mRNA levels of TLR-4.
Transcription (levels) of TLR-4
7) Confidence 0.66 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.63 Pain Relevance 0.17
LPS supplement significantly increased TLR4 protein and mRNA expression of intestinal mucosa in thermal injured mice in comparison with commensal depletion + burn group.


Transcription (expression) of TLR4 protein associated with burns
8) Confidence 0.53 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.85 Pain Relevance 0
In the kidney, the majority of the constitutive TLR2 and TLR4 mRNA is expressed by tubular epithelial cells (TECs) and is enhanced upon renal ischemia/reperfusion (I/R) injury as shown by in situ hybridization [14].
Transcription (expressed) of TLR4 in kidney associated with ischemia and injury
9) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.52 Pain Relevance 0.16
At the transcription level, four hours of LPS treatment at 1 µgmL?
Transcription (transcription) of LPS
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.23 Pain Relevance 0.28
However, in this study, Asp299Gly and Thr399Ile polymorphisms of TLR4 were not detected in all the 243 subjects.


Neg (not) Transcription (detected) of TLR4
11) Confidence 0.46 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291505 Disease Relevance 0.86 Pain Relevance 0
For instance, LPS is extracted from the bacterial membrane by the LPS-binding protein (LBP) after which it is transferred to CD14.
Transcription (extracted) of LPS
12) Confidence 0.41 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.06 Pain Relevance 0.03
Subsequently, they were injected with LPS from E. coli (serotype 0111:B4) at the doses of 450 mg/kg (CF1 mice) or 1000 ?
Transcription (injected) of LPS
13) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.39 Pain Relevance 0.08
After the last swimming session, mice were treated with LPS from E. coli (450 ?
Transcription (treated) of LPS
14) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.06 Pain Relevance 0.14
For instance, LPS is extracted from the bacterial membrane by the LPS-binding protein (LBP) after which it is transferred to CD14.
Transcription (extracted) of LPS
15) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.06 Pain Relevance 0.03
MyD88, TLR2, and TLR4 mRNA expression in primary microglia were
Transcription (expression) of TLR4 in microglia
16) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.18 Pain Relevance 0.09
The total area occupied by lymphoid follicles was larger in the LPS+rPorB/challenged group (?
Transcription (group) of LPS in follicles
17) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.25 Pain Relevance 0.07
mRNA expression, there were no significant changes in COX-2 mRNA expression of LPS versus LPS plus parthenolide co-treated animals.
Transcription (expression) of LPS
18) Confidence 0.19 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.12 Pain Relevance 0.14
mRNA expression, there were no significant changes in COX-2 mRNA expression of LPS versus LPS plus parthenolide co-treated animals.
Transcription (expression) of LPS
19) Confidence 0.18 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.12 Pain Relevance 0.14
The mRNA expression for TLR2 and TLR4 in the lung is increased by the combined exposure to washed DEP + LPS.
Transcription (expression) of TLR4 in lung
20) Confidence 0.17 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.45 Pain Relevance 0.16

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