INT185321

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.97
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) signal transduction (Tlr4) extracellular region (Il6)
plasma membrane (Tlr4) intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
brain 2
spleen 2
Tlr4 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 102 95.96 Very High Very High Very High
Inflammation 117 93.44 High High
cINOD 1 68.40 Quite High
Inflammatory mediators 5 67.84 Quite High
Spinal cord 1 40.40 Quite Low
chemokine 16 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 93.52 High High
INFLAMMATION 136 93.44 High High
Disease 4 89.96 High High
Death 3 77.72 Quite High
Shock 2 76.68 Quite High
Infection 2 69.80 Quite High
Necrosis 12 66.84 Quite High
Cancer 13 66.48 Quite High
Bacterial Infection 2 63.20 Quite High
Neurodegenerative Disease 5 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS-induced elevations of serum TNF, IL-1, and IL-6 levels were also less in germfree mice [11, 12].
LPS Positive_regulation (elevations) of Gene_expression (levels) of IL-6
1) Confidence 0.14 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.65 Pain Relevance 0.31
treated microglial cell cultures [32,33] and reduced the LPS-induced Il6 production in brain microglia in vivo [34].
LPS Positive_regulation (induced) of Gene_expression (production) of Il6 in brain
2) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.58 Pain Relevance 0.38
Co-treatment with parthenolide caused a 35 percent reduction in LPS-induced IL-6 production compared to animals treated with LPS alone (P < 0.05).


LPS Positive_regulation (induced) of Gene_expression (production) of IL-6
3) Confidence 0.11 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0 Pain Relevance 0
Parthenolide co-treatment in vivo impairs LPS-induced IL-6 mRNA expression in spleen but not liver
LPS Positive_regulation (induced) of Gene_expression (expression) of IL-6 mRNA in spleen
4) Confidence 0.11 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0 Pain Relevance 0
In order to determine the systemic effect of parthenolide co-treatment on LPS-induced IL-6 production, mice were treated with parthenolide (5 mg/kg, i.p.) and LPS (1 mg/kg, i.p.) for 90 minutes.
LPS Positive_regulation (induced) of Spec (determine) Gene_expression (production) of IL-6
5) Confidence 0.11 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0 Pain Relevance 0.03
and IL-6, and the expression of iNOS and COX-2 activated by LPS.
LPS Positive_regulation (activated) of Gene_expression (expression) of IL-6
6) Confidence 0.02 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC1978242 Disease Relevance 0.75 Pain Relevance 0.43

General Comments

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