INT185330

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 1.34

plasma membrane (Hrh1, Tac1) extracellular space (Tac1) signal transduction (Hrh1) extracellular region (Tac1) nucleus (Hrh1) cytoplasm (Hrh1)

Hrh1 (Mus musculus) Tac1 (Mus musculus)

Pain Link Frequency Relevance Heat substance P 74 98.84 antagonist 16 96.48 qutenza 20 92.04 Dorsal horn 10 86.48 Spinal cord 14 76.72 Glutamate receptor 5 63.40 Calcitonin gene-related peptide 1 56.64 Somatostatin 1 54.64 Neuropeptide 5 53.72 primary afferent fibers 11 52.24

Disease Link Frequency Relevance Heat Bordatella Infection 2 100.00 Targeted Disruption 3 43.76 Nociception 19 10.16 Pain 3 5.00 Hypersensitivity 2 5.00 Sprains And Strains 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NK1Rs couple with either the pertussis toxin (PTX)-insensitive Gq/G11 family [17] or PTX-sensitive Gi/Go family depending on cell types [18,19].

pertussis toxin Binding (couple) of NK1Rs associated with bordatella infection

1) Confidence 0.00 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.10 Pain Relevance 1.34

General Comments

This test has worked.