INT185373

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.96
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR2) cytosol (IRF6) signal transduction (TLR2)
plasma membrane (TLR2) intracellular (TLR2) nucleus (IRF6)
IRF6 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 66 99.76 Very High Very High Very High
Inflammatory mediators 5 98.40 Very High Very High Very High
rheumatoid arthritis 110 93.00 High High
Inflammation 35 77.76 Quite High
Arthritis 8 56.32 Quite High
agonist 12 5.32 Low Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 68 98.40 Very High Very High Very High
INFLAMMATION 45 98.00 Very High Very High Very High
Rheumatoid Arthritis 112 93.00 High High
Nicotine Addiction 66 75.04 Quite High
Pulmonary Disease 40 66.68 Quite High
Pneumococcal Infection 1 63.20 Quite High
Aging 1 45.12 Quite Low
Arthritis 12 28.88 Quite Low
Hypercalcemia 2 21.92 Low Low
Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
What are the possible consequences of LPS-stimulated TLR2 expression?
LPS Spec (possible) Positive_regulation (stimulated) of Gene_expression (expression) of TLR2
1) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.74 Pain Relevance 0.05
TLR2 and TLR4 gene expressions decreased in response to cytokine mix, while LPS enhanced TLR2 expression in HC and depressed TLR4 expression in OA patients.
LPS Positive_regulation (enhanced) of Gene_expression (expression) of TLR2 associated with osteoarthritis and cytokine
2) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Abstract Doc Link PMC2435281 Disease Relevance 1.17 Pain Relevance 0.57
TLR2 gene expression was significantly increased by LPS in healthy controls, while significant suppression of TL4 mRNA
LPS Positive_regulation (increased) of Gene_expression (expression) of TLR2 gene
3) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.05 Pain Relevance 0.42

General Comments

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