INT185379

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (IRF6, TLR2) cytosol (IRF6) signal transduction (TLR2)
plasma membrane (TLR2) intracellular (TLR2) nucleus (IRF6)
IRF6 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 98.88 Very High Very High Very High
tolerance 3 97.36 Very High Very High Very High
Inflammatory mediators 3 95.80 Very High Very High Very High
rheumatoid arthritis 10 78.08 Quite High
Inflammatory response 18 52.00 Quite High
headache 4 48.12 Quite Low
cytokine 14 14.52 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pseudomonas Infection 2 100.00 Very High Very High Very High
INFLAMMATION 47 98.88 Very High Very High Very High
Disease 84 89.56 High High
Autoimmune Disease 2 85.20 High High
Shock 4 79.24 Quite High
Rheumatoid Arthritis 10 78.08 Quite High
Injury 2 76.80 Quite High
Systemic Lupus Erythematosus 1 74.40 Quite High
Nicotine Addiction 67 72.44 Quite High
Pneumococcal Infection 1 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS, isolated from Pseudomonas aeruginosa and E. coli, and LTA, isolated from Staphylococcus aureus, were purchased from Sigma (Sigma Aldrich, Singapore) and were used as ligands for TLR4 and TLR2/TLR6 at concentrations from 10 ng/ml to 10 ?
LPS Binding (ligands) of TLR2 associated with pseudomonas infection
1) Confidence 0.08 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.10 Pain Relevance 0
TLR2 and TLR4 recognize lipoproteins and lipopolysaccharide (LPS), respectively.
LPS Binding (recognize) of TLR2
2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.69 Pain Relevance 0.21
Whole gram-negative bacteria are recognized not only through TLR4 (by LPS) but also TLR 2 (by bacterial lipopeptides).
LPS Binding (recognized) of TLR 2
3) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.79 Pain Relevance 0.05
However, LPS from some bacterial species, such as P. gingivalis, activate cells through TLR2 binding.
LPS Binding (binding) of TLR2
4) Confidence 0.01 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2701955 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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