INT185381

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, TLR2) plasma membrane (TNF, TLR2) intracellular (TNF, TLR2)
extracellular space (TNF) extracellular region (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 106 96.12 Very High Very High Very High
Osteoarthritis 2 93.28 High High
Inflammatory mediators 3 88.96 High High
cytokine 21 59.28 Quite High
Inflammation 24 58.92 Quite High
dexamethasone 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Etanercept 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 103 96.12 Very High Very High Very High
Osteoarthritis 2 93.28 High High
INFLAMMATION 31 88.96 High High
Disease 14 87.24 High High
Nicotine Addiction 66 86.16 High High
Pulmonary Disease 40 77.80 Quite High
Systemic Sclerosis 3 70.80 Quite High
Systemic Lupus Erythematosus 3 68.48 Quite High
Autoimmune Disease 5 65.60 Quite High
Pneumococcal Infection 1 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 was found to be up-regulated by TNF- and inhibited by SB-203580 [31].
TNF Regulation (regulated) of TLR2
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.22 Pain Relevance 0.36
In addition, differential regulation of TLR2 by IL-1, IL-10 and GM-CSF (upregulation) and IFN-gamma, TNF-?
TNF Regulation (regulation) of TLR2
2) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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