INT185385

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.63
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2, TLR4) plasma membrane (TLR2, TLR4) intracellular (TLR2, TLR4)
cytoplasm (TLR2, TLR4)
TLR2 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 98.88 Very High Very High Very High
Inflammatory mediators 4 95.80 Very High Very High Very High
Arthritis 2 86.88 High High
rheumatoid arthritis 10 74.80 Quite High
Inflammatory response 7 52.00 Quite High
fibrosis 3 51.60 Quite High
chemokine 7 43.84 Quite Low
cytokine 13 41.20 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 37 98.88 Very High Very High Very High
Sarcoidosis 40 94.40 High High
Syndrome 19 90.48 High High
Disease 90 89.56 High High
Vasculitis 2 89.28 High High
Arthritis 2 86.88 High High
Fever 1 86.00 High High
Lymphadenopathy 1 83.92 Quite High
Autoimmune Disease 3 81.92 Quite High
Shock 4 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whole gram-negative bacteria are recognized not only through TLR4 (by LPS) but also TLR 2 (by bacterial lipopeptides).
TLR 2 Binding (recognized) of TLR4
1) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.79 Pain Relevance 0.05
For example, mycobacteria contain ligands for TLR2 and TLR4.
TLR2 Binding (ligands) of TLR4
2) Confidence 0.22 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.22 Pain Relevance 0.07
TLR2 and TLR4 recognize lipoproteins and lipopolysaccharide (LPS), respectively.
TLR2 Binding (recognize) of TLR4
3) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.63 Pain Relevance 0.20

General Comments

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