INT18539

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 3.08
Pain Relevance 12.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
chromaffin cells 15
neurons 4
area postrema 3
tooth 1
VLM 1
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 32 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
Enkephalin 42 99.72 Very High Very High Very High
Neuropeptide 24 99.60 Very High Very High Very High
cva 5 99.54 Very High Very High Very High
Clonidine 33 99.38 Very High Very High Very High
medulla 38 99.32 Very High Very High Very High
substance P 13 99.00 Very High Very High Very High
Calcitonin gene-related peptide 2 98.00 Very High Very High Very High
Acupuncture 8 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toothache 2 99.92 Very High Very High Very High
Cv General 3 Under Development 4 99.54 Very High Very High Very High
Toxocariasis 6 98.32 Very High Very High Very High
Cancer 2 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 3 95.76 Very High Very High Very High
Pain 10 93.64 High High
Cold Sores 2 89.20 High High
Injury 12 84.12 Quite High
Neuropathic Pain 10 79.36 Quite High
Hyperalgesia 4 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison, PNMT mRNA was expressed preferentially in cells at the outer margin of the adrenal medulla from the earliest stage detectable.
Gene_expression (expressed) of PNMT mRNA in adrenal medulla associated with medulla
1) Confidence 0.78 Published 1989 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 2816486 Disease Relevance 0 Pain Relevance 0.39
This study evaluates the ability of clonidine and related drugs to regulate expression of the gene for the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in the rat adrenal gland and in bovine adrenal chromaffin cell cultures.
Gene_expression (synthesizing) of PNMT in chromaffin cell associated with clonidine
2) Confidence 0.75 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.39
Expression of c-Fos, a neuronal activation marker, and the phenylethanalamine-N-methyltransferase (PNMT) were examined 1.5 hours after noxious intrapulpal tooth stimulation.
Gene_expression (Expression) of PNMT in tooth
3) Confidence 0.75 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 17163588 Disease Relevance 0.19 Pain Relevance 0.36
Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.
Gene_expression (express) of PNMT in neurons
4) Confidence 0.75 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.60
Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.
Gene_expression (synthesizing) of PNMT in neurons
5) Confidence 0.75 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.60
These immortalized loxTsTag/CrePR1/RAD cells expressed immunoreactivities (ir) for all the catecholamine enzymes: tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DbetaH), and phenylethanolamine-N-methyltransferase (PNMT).
Gene_expression (expressed) of PNMT associated with dopamine and catecholamine
6) Confidence 0.75 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12009759 Disease Relevance 0.34 Pain Relevance 0.23
A 15% haemorrhage significantly induced expression of PNMT in the rostral C1 region and NPY in the caudal C1 and A1 regions but had no effect on ENK at any sites, suggesting a differential regulation on the expression of these three genes in the VLM.
Gene_expression (expression) of PNMT in VLM associated with medulla and cva
7) Confidence 0.75 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12782392 Disease Relevance 0.73 Pain Relevance 0.57
This study evaluates the ability of clonidine and related drugs to regulate expression of the gene for the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in the rat adrenal gland and in bovine adrenal chromaffin cell cultures.
Gene_expression (expression) of PNMT in chromaffin cell associated with clonidine
8) Confidence 0.75 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.39
We conclude that before birth, adrenaline synthesis may be suppressed by a novel direct, or indirect, inhibitory effect of glucocorticoids on PNMT mRNA expression.
Gene_expression (expression) of PNMT mRNA
9) Confidence 0.74 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.07
Phenylethanolamine-N-methyltransferase, the enzymatic marker found only in adrenergic neurons, was detected immunocytochemically in terminals distributed throughout the area postrema and in neuronal perikarya and varicosities within the adjacent mNTS.
Gene_expression (detected) of Phenylethanolamine-N-methyltransferase in area postrema associated with increased venous pressure under development
10) Confidence 0.74 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0.10 Pain Relevance 0.57
Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.
Gene_expression (synthesizing) of phenylethanolamine N-methyltransferase in neurons
11) Confidence 0.72 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.60
Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.
Gene_expression (express) of phenylethanolamine N-methyltransferase in neurons
12) Confidence 0.72 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.60
Developmental expression of proenkephalin A mRNA and phenylethanolamine N-methyltransferase mRNA in foetal sheep adrenal medulla.
Gene_expression (expression) of phenylethanolamine N-methyltransferase in adrenal medulla associated with medulla and enkephalin
13) Confidence 0.67 Published 1989 Journal Int. J. Dev. Neurosci. Section Title Doc Link 2816486 Disease Relevance 0 Pain Relevance 0.38
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Gene_expression (selective) of PNMT
14) Confidence 0.65 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07
These grafted chromaffin cells also expressed immunoreactivities for the other catecholamine-synthesizing enzymes 7 weeks after grafting, including: dopamine-beta-hydroxylase (DbetaH) and phenylethanolamine-N-methyltransferase (PNMT).
Gene_expression (expressed) of PNMT in chromaffin cells associated with dopamine and catecholamine
15) Confidence 0.65 Published 2000 Journal Cell Transplant Section Abstract Doc Link 11144961 Disease Relevance 0.63 Pain Relevance 0.99
No such enhancers were found in DBH or PNMT promoters, and both catecholamine system-related gene promoters were unaffected by butyrate.
Neg (No) Gene_expression (found) of PNMT associated with catecholamine
16) Confidence 0.65 Published 2005 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 16165221 Disease Relevance 0 Pain Relevance 0.05
Glucocorticoids decrease phenylethanolamine N-methyltransferase mRNA expression in the immature foetal sheep adrenal.
Gene_expression (expression) of phenylethanolamine N-methyltransferase associated with enkephalin
17) Confidence 0.65 Published 1999 Journal J. Neuroendocrinol. Section Title Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.18
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Gene_expression (synthesizing) of PNMT in area postrema associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
18) Confidence 0.58 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.42
The developmental expression of neuropeptide Y (NPY) and leucine-enkephalin (L-Enk) was examined in embryonic, early postnatal, and adult chromaffin cells with double- and triple-label immunocytochemical techniques and compared to the expression of immunoreactivity for tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT).
Gene_expression (expression) of PNMT in chromaffin cells associated with neuropeptide and enkephalin
19) Confidence 0.58 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1975838 Disease Relevance 0 Pain Relevance 0.22
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Gene_expression (synthesizing) of phenylethanolamine-N-methyltransferase in area postrema associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
20) Confidence 0.57 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.42

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