INT185393

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.48
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PVRL1) cell adhesion (PVRL1) plasma membrane (PVRL1)
Anatomy Link Frequency
monocytes 1
immune system 1
PVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 24 98.64 Very High Very High Very High
Inflammation 11 97.84 Very High Very High Very High
chemokine 3 97.32 Very High Very High Very High
cytokine 10 96.84 Very High Very High Very High
Potency 3 80.80 Quite High
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
GABA receptor 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 6 98.64 Very High Very High Very High
Influenza Virus Infection 67 98.20 Very High Very High Very High
INFLAMMATION 15 97.84 Very High Very High Very High
Aging 3 97.24 Very High Very High Very High
Sprains And Strains 68 92.88 High High
Pulmonary Disease 41 85.04 High High
Viral Infection 1 69.52 Quite High
Nicotine Addiction 67 67.48 Quite High
Bacterial Infection 3 53.68 Quite High
Lower Respiratory Tract Infection 1 43.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A disturbed regulation of PRR on monocytes and AM may affect the recognition of bacterial pathogens and the intracellular signaling as well as resulting effector mechanisms.
Regulation (regulation) of PRR in monocytes
1) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.52 Pain Relevance 0.07
In addition to the adaptive immune system, concomitant dysregulation of the innate immune system with aging plays a major role in the response to influenza vaccine and infection in older adults in several ways, including: 1) altered expression, regulation, and function of PRR and costimulatory molecules; 2) altered secretion of inflammatory chemokines, cytokines, and anti-microbial peptides; and 3) decreased function of NK cells, macrophages, and neutrophils [31,32].
Regulation (regulation) of PRR in immune system associated with chemokine, aging, inflammation, influenza virus infection, infection and cytokine
2) Confidence 0.06 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.72 Pain Relevance 0.18
was the most sensitive PRR mutant, and xrs2?
Regulation (sensitive) of PRR
3) Confidence 0.03 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.17 Pain Relevance 0.15
The observation that NER, PRR, and HR mutants are all sensitive to compound 15 is reminiscent of tolerance of damage caused by cisplatin, which requires all three of these repair pathways [30]–[33].
Regulation (sensitive) of PRR associated with tolerance
4) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.08 Pain Relevance 0.05

General Comments

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