INT185394

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.94
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PVRL1) cell adhesion (PVRL1) plasma membrane (PVRL1)
Anatomy Link Frequency
plasma 1
immune system 1
PVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 58 95.24 Very High Very High Very High
Inflammatory mediators 3 84.52 Quite High
Inflammation 32 42.56 Quite Low
chemokine 12 39.52 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 6 100.00 Very High Very High Very High
Herpes Zoster 1 99.92 Very High Very High Very High
Viral Infection 10 99.24 Very High Very High Very High
Cytomegalovirus Infection 119 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 37 98.36 Very High Very High Very High
Infection 86 96.80 Very High Very High Very High
Influenza Virus Infection 135 95.60 Very High Very High Very High
Pneumococcal Infection 1 94.88 High High
Blindness 6 94.28 High High
Retinitis 81 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, TLR2 is the main PRR recognizing gram-positive bacteria, and recent studies have shown that TLR2 -deficient animals are at high risk for succumbing to invasive pneumococcal infections [18].
PRR Binding (recognizing) of associated with pneumococcal infection
1) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.75 Pain Relevance 0.04
Another group of cytoplasmic PRR are the RLR, which include RNA helicases such as RIG-I that recognize 5’ triphosphate ssRNA and dsRNA.
cytoplasmic PRR Binding (recognize) of
2) Confidence 0.08 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.53 Pain Relevance 0.05
The innate immune system is activated by germline encoded invariant pattern recognition receptors (PRR) that recognize cellular damage or a broad array of pathogens by recognizing unique conserved sequences known as Pathogen-Associated Molecular Patterns (PAMP); important examples of PRR include Toll-Like Receptors (TLR), Nucleotide-binding domain and Leucine-rich-repeat Receptors (NLR), and Retinoic acid-inducible gene-I Like Receptors (RLR).
PRR Binding (recognize) of in immune system
3) Confidence 0.08 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.22 Pain Relevance 0
Other factors that may affect viral entry and/or intracellular signalling include: (1) the capability of gB to rapidly mobilize lipid rafts [7, 8], and (2) the release of plasma membrane Ca2+ stores and the increase in intracellular Ca2+ triggered by the engagement of nectin by gD and of integrin ?
nectin Binding (engagement) of in plasma
4) Confidence 0.07 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.43 Pain Relevance 0
It interferes with the binding of the diphosphate to the viral DNA polymerase of Herpes simplex, Varicella zoster, cytomegalovirus, and HIV.28
Herpes simplex Binding (binding) of associated with herpes simplex virus, acquired immune deficiency syndrome or hiv infection, herpes zoster and cytomegalovirus infection
5) Confidence 0.00 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861935 Disease Relevance 1.01 Pain Relevance 0

General Comments

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