INT185396

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 15.18
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PVRL1) cell adhesion (PVRL1) plasma membrane (PVRL1)
Anatomy Link Frequency
monocytes 5
macrophage 1
immune system 1
blood cells 1
PVRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 101 97.84 Very High Very High Very High
chemokine 32 97.32 Very High Very High Very High
cytokine 71 96.84 Very High Very High Very High
Inflammatory marker 12 91.92 High High
tolerance 14 85.12 High High
Potency 2 80.40 Quite High
Inflammatory response 3 78.72 Quite High
Versed 12 72.00 Quite High
anesthesia 12 69.60 Quite High
Inflammatory mediators 43 64.72 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 92 99.84 Very High Very High Very High
Pulmonary Disease 481 99.52 Very High Very High Very High
Nicotine Addiction 793 99.36 Very High Very High Very High
Infection 33 98.88 Very High Very High Very High
Influenza Virus Infection 67 98.44 Very High Very High Very High
INFLAMMATION 160 97.84 Very High Very High Very High
Aging 14 97.48 Very High Very High Very High
Sepsis 12 96.16 Very High Very High Very High
Cancer 71 95.64 Very High Very High Very High
Sprains And Strains 53 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the regulation of PRR expression after ligand stimulation, cells were exposed to LPS (1 ?
Gene_expression (expression) of PRR
1) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.19 Pain Relevance 0
Regarding the effect of chronic smoke exposure on blood cells we did not find any difference in the PRR expression on monocytes between smokers and non-smokers (data not shown) suggesting a compartmentalized effect of tobacco smoking.
Gene_expression (expression) of PRR in blood cells associated with nicotine addiction
2) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.12 Pain Relevance 0.04
Pathogen recognition receptors (PRR) which are expressed on the macrophage's surface mediate the interaction between conserved patterns on microorganisms, pathogen associated molecular patterns (PAMP's), and host cells [6].
Gene_expression (expressed) of PRR in macrophage
3) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.42 Pain Relevance 0.04
Regulation of PRR expression on AM
Gene_expression (expression) of PRR
4) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.19 Pain Relevance 0
However this factor seems to be without influence on our results since comparable levels of PRR expression on monocytes and AM from healthy young and elderly non-smokers were observed.
Gene_expression (expression) of PRR in monocytes associated with nicotine addiction
5) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.85 Pain Relevance 0.16
A change in the PRR expression on AM from COPD patients may therefore be involved in the process of continuing inflammation and bacterial colonization.
Gene_expression (expression) of PRR associated with pulmonary disease and inflammation
6) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.58 Pain Relevance 0.08
PRR expression of AM from non-smokers, smokers, COPD patients
Gene_expression (expression) of PRR associated with pulmonary disease and nicotine addiction
7) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.28 Pain Relevance 0
The generally lower expression of PRR's on AM's compared to monocytes is comparable to data reported for dendritic cells and may accompany the differentiation process of monocytes to macrophage populations [15].
Gene_expression (expression) of PRR in monocytes
8) Confidence 0.30 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.13 Pain Relevance 0.04
A number of proteins important for the formation of adherens junctions, such as vinculin, alpha 1 actinin and poliovirus receptor-related 1 protein were found to be overexpressed in pancreatic cancer serum.
Gene_expression (overexpressed) of poliovirus receptor-related 1 protein associated with pancreatic cancer
9) Confidence 0.29 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.14 Pain Relevance 0.05
A number of proteins important for the formation of adherens junctions, such as vinculin, alpha 1 actinin and poliovirus receptor-related 1 protein were found to be overexpressed in pancreatic cancer serum.
Gene_expression (actinin) of poliovirus receptor-related 1 protein associated with pancreatic cancer
10) Confidence 0.29 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 1.14 Pain Relevance 0.05
In the non-smoker group two age groups were recruited to exclude an age specific effect of PRR expression (young [A], elderly [B]).
Gene_expression (expression) of PRR
11) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.88 Pain Relevance 0.18
In our study we asked whether chronic cigarette smoke exposure alters the expression of PRR's in human monocytes/AM ex vivo.
Gene_expression (expression) of PRR in monocytes
12) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.68 Pain Relevance 0.07
There was no significant difference in the PRR expression on monocytes from non-smokers (A and B), smokers, COPD patients.
Gene_expression (expression) of PRR in monocytes associated with pulmonary disease and nicotine addiction
13) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.29 Pain Relevance 0
We observed a significantly decreased expression of PRR's on AM compared to monocytes.
Gene_expression (expression) of PRR in monocytes
14) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.10 Pain Relevance 0
In addition to the adaptive immune system, concomitant dysregulation of the innate immune system with aging plays a major role in the response to influenza vaccine and infection in older adults in several ways, including: 1) altered expression, regulation, and function of PRR and costimulatory molecules; 2) altered secretion of inflammatory chemokines, cytokines, and anti-microbial peptides; and 3) decreased function of NK cells, macrophages, and neutrophils [31,32].
Gene_expression (expression) of PRR in immune system associated with chemokine, aging, inflammation, influenza virus infection, infection and cytokine
15) Confidence 0.13 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.72 Pain Relevance 0.18
was the most sensitive PRR mutant, and xrs2?
Gene_expression (mutant) of PRR
16) Confidence 0.04 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2583946 Disease Relevance 0.17 Pain Relevance 0.15
Sig. pathways), IL-6 (TREM1, PRR, IL-10 and IL-6 pathways) and CCL5 (PRR and Chem.
Gene_expression (pathways) of PRR
17) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.29 Pain Relevance 0.13

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