INT185397

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
macrophages 2
MD2 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 15 94.36 High High
cytokine 29 76.60 Quite High
Inflammation 27 66.64 Quite High
Inflammatory response 15 52.84 Quite High
chemokine 4 50.20 Quite High
anesthesia 2 22.12 Low Low
Versed 1 20.88 Low Low
Inflammatory marker 1 11.36 Low Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 5 90.04 High High
Bacterial Respiratory Disease 1 70.48 Quite High
INFLAMMATION 44 66.64 Quite High
Immune Reconstitution Inflammatory Syndrome 31 58.56 Quite High
Nicotine Addiction 66 50.00 Quite Low
Pulmonary Disease 40 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 50.00 Quite Low
Mycobacterial Infection 19 50.00 Quite Low
Sleep Disorders 1 20.28 Low Low
Infection 9 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding and activation of LPS to TLR4 needs three additional components: MD2, a membrane protein whose association with TLR4 is required for the binding of LPS [5]; LPS-binding protein (LBP), which extracts LPS monomers from the aggregated form [6,7]; and CD14, which transfers LPS to the TLR4/MD2 transmembrane co-receptor, which then triggers the downstream molecular events [2].
Positive_regulation (required) of LPS Binding (binding) of in MD2
1) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.18 Pain Relevance 0.11
The CD14/TLR complex and associated signaling pathways are essential for the recognition of LPS by macrophages, and several studies suggest that down-regulation of CD14/TLR complexes on macrophages is responsible for the development of tolerance [63,70,75,76].
Positive_regulation (essential) of LPS Binding (recognition) of in macrophages associated with tolerance
2) Confidence 0.11 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.39 Pain Relevance 0.47
Preliminary experiments testing increasing LPS concentrations demonstrated a dose-dependent effect (TLR expression on AM in response to 0.1 ?
Positive_regulation (increasing) of LPS Binding (concentrations) of
3) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0 Pain Relevance 0

General Comments

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