INT185398

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 27.21
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
monocytes 11
alveolar macrophages 11
macrophages 6
nasal epithelium 2
Neutrophils 2
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 90 100.00 Very High Very High Very High
cytokine 429 99.40 Very High Very High Very High
Inflammation 277 96.32 Very High Very High Very High
rheumatoid arthritis 199 96.04 Very High Very High Very High
Inflammatory mediators 30 95.20 Very High Very High Very High
chemokine 71 88.36 High High
Arthritis 32 80.72 Quite High
Inflammatory response 43 72.24 Quite High
metalloproteinase 3 58.32 Quite High
agonist 53 47.12 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 447 100.00 Very High Very High Very High
Pulmonary Disease 242 100.00 Very High Very High Very High
Low Back Pain 90 100.00 Very High Very High Very High
Uveitis 238 99.84 Very High Very High Very High
Disease 234 99.52 Very High Very High Very High
Insulin Resistance 30 99.52 Very High Very High Very High
Necrosis 16 99.48 Very High Very High Very High
Myocardial Infarction 14 99.36 Very High Very High Very High
Cancer 25 99.30 Very High Very High Very High
Sarcoidosis 120 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main finding was that AM from COPD patients and smokers show an equally decreased surface expression of TLR2 compared to non-smokers of two age groups.
Negative_regulation (decreased) of Gene_expression (expression) of TLR2 associated with nicotine addiction and pulmonary disease
1) Confidence 0.55 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.99 Pain Relevance 0
Our data demonstrating an altered AM phenotype with reduced expression of TLR2 in smokers and COPD patients suggest that a continuous exposure to microbial products in this disease provided by bacterial colonization and LPS present in tobacco smoke [5] may downmodulate the pulmonary immune response.
Negative_regulation (reduced) of Gene_expression (expression) of TLR2 associated with pulmonary disease, nicotine addiction and disease
2) Confidence 0.55 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.61 Pain Relevance 0.26
Our observation of reduced TLR2 surface expression on alveolar macrophages coincides functionally with the lower production of TNF-?
Negative_regulation (reduced) of Gene_expression (expression) of TLR2 in alveolar macrophages
3) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.07 Pain Relevance 0.03
TLR2 cell surface expression by flow cytometry was decreased on monocytes after stimulation with Pam3Cys, whereas the expression of TLR2 on alveolar macrophages in response to Pam3Cys remained unchanged.
Negative_regulation (decreased) of Gene_expression (expression) of TLR2 in alveolar macrophages
4) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.09
The expression of TLR2, TLR4 and CD14 on AM from COPD patients, smokers and non-smokers was reduced as compared to autologous monocytes.
Negative_regulation (reduced) of Gene_expression (expression) of TLR2 in monocytes associated with nicotine addiction and pulmonary disease
5) Confidence 0.41 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1187924 Disease Relevance 1.63 Pain Relevance 0.03
Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients

Backround

Negative_regulation (decreased) of Gene_expression (expression) of Toll-like receptor 2 in alveolar macrophages associated with pulmonary disease and nicotine addiction
6) Confidence 0.41 Published 2005 Journal Respir Res Section Title Doc Link PMC1187924 Disease Relevance 0.91 Pain Relevance 0.04
Comparing AM from non-smokers (A and B), smokers and COPD patients we detected a markedly lower expression of TLR2 on AM from smokers and COPD patients (13.98 ± 2.54 and 12.07 ± 3.5 [nonsmoker groups] vs. 6.59 ± 1.42 and 6.08 ± 1.5 rMFI, respectively, p < 0.01) (figure 2a).
Negative_regulation (lower) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
7) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.40 Pain Relevance 0
Corresponding with the reduced surface and mRNA expression of TLR2, Pam3Cys induced lower production of TNF-?
Negative_regulation (reduced) of Gene_expression (expression) of TLR2
8) Confidence 0.39 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.10
Interestingly, TLR2 surface expression (rMFI) and the proportion of TLR2 positive cells decreased after 24 hours of culture in Petri dishes and through day 7 (D7) when cells portrayed a macrophage phenotype as determined by light microscopy (Day 0, basal rMFI 3.9 ± 0.9, 54 ± 10.4%; Day 4 rMFI 1.4 ± 0.36, 8.5 ± 7.8%, Day 7 rMFI 1.4 ± 0.5, 1.5 ± 1.2%, p < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of TLR2 in macrophage
9) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
These results are also compatible with those from Henning et al who reported a significant reduction of TLR2 protein and mRNA, and unaltered TLR4 expression during the in vitro maturation of human monocytes to macrophages in Teflon wells [39].
Negative_regulation (reduction) of Gene_expression (expression) of TLR2 in macrophages
10) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.08 Pain Relevance 0.03
These results are also compatible with those from Henning et al who reported a significant reduction of TLR2 protein and mRNA, and unaltered TLR4 expression during the in vitro maturation of human monocytes to macrophages in Teflon wells [39].
Negative_regulation (reported) of Gene_expression (expression) of TLR2 in macrophages
11) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.08 Pain Relevance 0.03
To assess the expression of TLR2, TLR4 and TLR9 by flow cytometry following ligand exposure, alveolar macrophages and monocytes were stimulated for the optimal incubation periods (described in the Methods section) with Pam3Cys (30 minutes), LPS (10 minutes) and M.tb DNA (24 hours), respectively.
Negative_regulation (assess) of Gene_expression (expression) of TLR2 in alveolar macrophages associated with mycobacterial infection
12) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.09 Pain Relevance 0
A deficiency in the expression of TLR2 and 4 may also explain the lack response of these cells to NTHi as well.
Negative_regulation (deficiency) of Gene_expression (expression) of TLR2 associated with hemophilus infection
13) Confidence 0.38 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1368979 Disease Relevance 0.93 Pain Relevance 0.03
Comparing AM we detected a reduced expression of TLR2 in COPD patients and smokers.
Negative_regulation (reduced) of Gene_expression (expression) of TLR2 associated with nicotine addiction and pulmonary disease
14) Confidence 0.35 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1187924 Disease Relevance 1.59 Pain Relevance 0.03
No evidence of altered alveolar macrophage polarization, but reduced expression of TLR2, in bronchoalveolar lavage cells in sarcoidosis

Background

Negative_regulation (reduced) of Gene_expression (expression) of TLR2 in alveolar macrophage associated with sarcoidosis
15) Confidence 0.35 Published 2010 Journal Respir Res Section Title Doc Link PMC2939603 Disease Relevance 0.77 Pain Relevance 0.05
There was a significantly reduced TLR2 gene expression in sorted AMs from sarcoidosis patients compared to healthy subjects (p = 0.024) (Fig. 6a).
Negative_regulation (reduced) of Gene_expression (expression) of TLR2 associated with sarcoidosis
16) Confidence 0.35 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.38 Pain Relevance 0
The reduced TLR2 expression of AMs from patients with Löfgren's syndrome may suggest a distinct innate immune response to pathogens in these patients.


Negative_regulation (reduced) of Gene_expression (expression) of TLR2 associated with syndrome
17) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.04 Pain Relevance 0
treatment decreases local and systemic expression of TLR2 and TLR4 receptors [16, 17].
Negative_regulation (decreases) of Gene_expression (expression) of TLR2
18) Confidence 0.34 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.39 Pain Relevance 0.80
Critically ill patients exhibited increase in TLR-3, 4, 7 and decrease in TLR-2 expressions.
Negative_regulation (decrease) of Gene_expression (expressions) of TLR-2 associated with critical illness
19) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.65 Pain Relevance 0.07
No significant differences were found in levels of TLR2 mRNA expression in PBMCs between patients with active BD, patients with inactive BD, and healthy control individuals (Figure 2a).
Negative_regulation (levels) of Gene_expression (expression) of TLR2 mRNA associated with disease
20) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.49 Pain Relevance 0

General Comments

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