INT185407

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 9.32
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
respiratory 2
SCN 1
sympathetic 1
face 1
lens 1
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
pain pelvic 95 99.98 Very High Very High Very High
Neurotransmitter 5 96.60 Very High Very High Very High
Neuropeptide 1 95.48 Very High Very High Very High
Acupuncture 115 89.88 High High
agonist 13 87.84 High High
Enkephalin 2 87.60 High High
Serotonin 52 87.48 High High
Opioid 31 86.88 High High
Pain 169 85.76 High High
Eae 1 85.40 High High
Disease Link Frequency Relevance Heat
Osteoporosis 53 100.00 Very High Very High Very High
Rhinitis 50 100.00 Very High Very High Very High
Reprotox - General 3 95 99.98 Very High Very High Very High
Weight Loss 44 99.98 Very High Very High Very High
Acidosis 25 99.98 Very High Very High Very High
Disease 61 99.82 Very High Very High Very High
Infection 34 99.38 Very High Very High Very High
Malaria 229 99.16 Very High Very High Very High
Disorder Of Lipid Metabolism 11 99.16 Very High Very High Very High
Cardiovascular Disease 20 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is also possible that a mechanism underlying part of the improvements in the physiotherapy group relates to the therapeutic environment including interaction with the therapist rather than the interventions per se.
per se Binding (interaction) of
1) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2830179 Disease Relevance 0.29 Pain Relevance 0.15
The generation of rhythmicity in the SCN is genetically determined and based on feedback loop that involves several genes, including Per1, Per2, and Clock.6,7 The SCN and its afferent and efferent pathways contain various neurotransmitters including neuropeptide Y, ?
Per1 Binding (genes) of in SCN associated with neurotransmitter and neuropeptide
2) Confidence 0.33 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.90
Consistent with the findings from other studies, patients who had chosen peritoneal dialysis were younger14,33,38–40 and had received more education12 than the patients who had chosen hemodialysis, although some studies found no relationship of age with treatment modality selection.12 It has been suggested15 that while physicians do not consider age per se to be a contraindication for home dialysis therapies,4,41–43 older age is associated with many medical and social comorbidities that make home dialysis difficult or impossible.4
per se Binding (contraindication) of associated with renal failure
3) Confidence 0.32 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2846137 Disease Relevance 0.75 Pain Relevance 0
Interaction between HDI and per capita family income was also assessed.


per capita Binding (Interaction) of
4) Confidence 0.31 Published 2010 Journal BMC Oral Health Section Body Doc Link PMC2928166 Disease Relevance 0.14 Pain Relevance 0.14
Research with this perspective represents both possibilities and limitations but fails to explore the phenomenon per se, i.e., the lived experience of initiating breastfeeding from women's perspectives.
per se Neg (fails) Binding (explore) of
5) Confidence 0.31 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2964113 Disease Relevance 0 Pain Relevance 0
For example, anecdotal evidence by one of the team members (CM) suggests that outbreaks of malaria infections in northern jungle regions of Perú are associated with movement patterns of timber merchants who enter the jungle at low river levels and exit when river levels rise.
Per Binding (associated) of associated with malaria and infection
6) Confidence 0.30 Published 2009 Journal Malar J Section Body Doc Link PMC2714521 Disease Relevance 0.64 Pain Relevance 0
It is worth pointing out that the authors have made use of the best, most complete data available, and while of course it is not ideal, it is reassuring that the patterns of persistence as a function of community size are quite clear in jungle areas which are the most remote and difficult to access in Perú.
Per Spec (clear) Binding (access) of
7) Confidence 0.30 Published 2009 Journal Malar J Section Body Doc Link PMC2714521 Disease Relevance 0.56 Pain Relevance 0
Poverty, either as a cause or an effect of epidemic disease, is not associated with terrorism per se, but impoverished regions of poorer countries have been argued to afford sympathetic (or coerced) havens for terrorist groups (UKFP), for which there is some empirical evidence [28].
per se Binding (associated) of in sympathetic associated with disease
8) Confidence 0.19 Published 2010 Journal Global Health Section Body Doc Link PMC2936293 Disease Relevance 0.50 Pain Relevance 0
That is why it is important to assess not only the risk factors associated with osteoporosis per se, which are fairly well-known, but also their prevalence in the general population.
per se Binding (associated) of associated with osteoporosis
9) Confidence 0.09 Published 2008 Journal The Open Rheumatology Journal Section Body Doc Link PMC2588091 Disease Relevance 1.01 Pain Relevance 0
Though weight loss per se, in combination with increased physical activity, is usually associated with an increase in HDL cholesterol and decreases in triglyceride and LDL cholesterol concentration, the beneficial effects on lipids of the caloric reduction in LoCHO diets appear to be secondary or additive to carbohydrate restriction and are seen even after adjusting for amount of weight loss[27].
per se Binding (associated) of associated with weight loss and disorder of lipid metabolism
10) Confidence 0.05 Published 2005 Journal Nutr Metab (Lond) Section Body Doc Link PMC1188071 Disease Relevance 1.56 Pain Relevance 0
In these elderly phakic patients, the lens status per se, in presence of an ocular biometric predisposition, synergistically interacting with paroxetine-induced passive mydriasis (via 5-HT7 receptors), easily can determine the glaucomatous attack [46, 71, 80].
per se Binding (interacting) of in lens associated with mydriatic
11) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701282 Disease Relevance 0.86 Pain Relevance 0.15
These three key meridians associated with PER flow together through the nose, and are therefore closely connected with respiratory function.
PER Binding (associated) of in respiratory associated with rhinitis
12) Confidence 0.03 Published 2009 Journal Trials Section Body Doc Link PMC2715403 Disease Relevance 0.53 Pain Relevance 0.31
There appears to be a difference in physiologic variables and outcomes between patients with respiratory acidosis and those with metabolic acidosis [1,2], leading some investigators to hypothesize that it is the cause of acidosis rather than the acidosis per se that drives the association with clinical outcomes.
per se Binding (association) of in respiratory associated with acidosis and acid base imbalance
13) Confidence 0.02 Published 2005 Journal Crit Care Section Body Doc Link PMC1297622 Disease Relevance 1.48 Pain Relevance 0
The midwives generally felt that PP per se was not associated with specific complications during pregnancy and delivery; however, if induced labour was chosen because of severe PP, the women would face the same risks faced by other women undergoing induced delivery.
per se Binding (associated) of in face associated with pain pelvic
14) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2964625 Disease Relevance 1.00 Pain Relevance 0.95

General Comments

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