INT185412

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.49
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CFD) extracellular space (CFD) extracellular region (CFD)
Anatomy Link Frequency
urine 1
CFD (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 8 86.80 High High
Bile 4 80.16 Quite High
Inflammation 64 72.88 Quite High
fibrosis 110 54.52 Quite High
Thalamus 26 52.32 Quite High
cytokine 14 41.24 Quite Low
Kinase C 2 10.04 Low Low
cINOD 6 7.52 Low Low
positron emission tomography 22 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 226 100.00 Very High Very High Very High
Dengue 104 98.16 Very High Very High Very High
Disease 48 97.96 Very High Very High Very High
Flavivirus Infection 80 97.64 Very High Very High Very High
Infection 40 93.48 High High
Cirrhosis 20 92.28 High High
Toxicity 2 92.24 High High
Injury 20 88.44 High High
Vomiting 2 84.08 Quite High
Sunburn 2 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After oral administration, PFD reaches its maximum levels in blood after 1 to 2 hours and is almost fully eliminated in urine after another 6 hours.
Negative_regulation (eliminated) of PFD in urine
1) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.41 Pain Relevance 0.04
PFD downregulated the elevated levels of these transcripts by 50 to 60%, which was associated with a 70% reduction in collagen deposition and downregulation of TGF-?
Negative_regulation (downregulated) of PFD
2) Confidence 0.20 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.58 Pain Relevance 0.10
The mean pre-PEP (visit 1) diastolic BP was 94.33 ± 6.37 and the mean diastolic BP on visit 4 was 85.66 ± 3.66, also a statistically significant decrease (t = 2.89, df = 5, p = 0.0341).
Negative_regulation (decrease) of df
3) Confidence 0.19 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778429 Disease Relevance 0.05 Pain Relevance 0
In contrast, it appears that when levels of factor D are not reduced, the patient develops the most severe form of the disease DHF (Table 2).
Neg (not) Negative_regulation (reduced) of factor D associated with flavivirus infection and disease
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.67 Pain Relevance 0
It is clear from Figure 9B that DF2 (CX717, green segments) and DF3 (sleep deprivation, blue segments) had large influences on regional CMRglc and tended to vary inversely across the three test conditions.
Negative_regulation (deprivation) of DF3 associated with sleep disorders
5) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1188239 Disease Relevance 0.36 Pain Relevance 0.03
It is clear from Figure 9B that DF2 (CX717, green segments) and DF3 (sleep deprivation, blue segments) had large influences on regional CMRglc and tended to vary inversely across the three test conditions.
Negative_regulation (deprivation) of DF2 associated with sleep disorders
6) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1188239 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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