INT185417

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2005
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.13
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5) small molecule metabolic process (ALOX5) endoplasmic reticulum (PLA2G2A)
cytoplasm (ALOX5) cytosol (ALOX5) extracellular space (PLA2G2A)
Anatomy Link Frequency
endocrine system 1
ALOX5 (Homo sapiens)
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 84 87.16 High High
Osteoarthritis 32 82.32 Quite High
Pain 3 76.80 Quite High
licofelone 45 71.76 Quite High
Inflammatory response 9 63.48 Quite High
cINOD 16 57.68 Quite High
Pain score 2 37.08 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crohn's Disease 327 96.36 Very High Very High Very High
Disease 126 91.92 High High
Injury 6 90.68 High High
Inflammatory Bowel Disease 234 89.04 High High
INFLAMMATION 86 87.16 High High
Osteoarthritis 33 82.32 Quite High
Skin Cancer 24 81.52 Quite High
Pain 5 76.80 Quite High
Pressure And Volume Under Development 3 56.80 Quite High
Cancer 28 14.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of phospholipase A2, group IIA (PLA2G2A), which has an inferred role in prostaglandin and leukotriene metabolism and was up-regulated in both subtypes, genes associated with leukotriene metabolism, such as arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP), leukotriene B4 receptor 2 (LTB4R2), and arginyl aminopeptidase (aminopeptidase B; RNPEP) were significantly down-regulated in the CD profile (Table 3).
arachidonate 5-lipoxygenase Binding (associated) of PLA2G2A associated with crohn's disease
1) Confidence 0.16 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.87 Pain Relevance 0.10
With the exception of phospholipase A2, group IIA (PLA2G2A), which has an inferred role in prostaglandin and leukotriene metabolism and was up-regulated in both subtypes, genes associated with leukotriene metabolism, such as arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP), leukotriene B4 receptor 2 (LTB4R2), and arginyl aminopeptidase (aminopeptidase B; RNPEP) were significantly down-regulated in the CD profile (Table 3).
ALOX5 Binding (associated) of PLA2G2A associated with crohn's disease
2) Confidence 0.16 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.87 Pain Relevance 0.10
With the exception of phospholipase A2, group IIA (PLA2G2A), which has an inferred role in prostaglandin and leukotriene metabolism and was up-regulated in both subtypes, genes associated with leukotriene metabolism, such as arachidonate 5-lipoxygenase (ALOX5), arachidonate 5-lipoxygenase-activating protein (ALOX5AP), leukotriene B4 receptor 2 (LTB4R2), and arginyl aminopeptidase (aminopeptidase B; RNPEP) were significantly down-regulated in the CD profile (Table 3).
arachidonate 5-lipoxygenase Binding (associated) of PLA2G2A associated with crohn's disease
3) Confidence 0.14 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.88 Pain Relevance 0.10
The pharmacological profile of LOX/COX inhibitors is quite similar to that of glucocorticoids drugs, which inhibit PLA2 and thereby prevent arachidonic metabolism by both COX and 5-LOX, without the severe adverse events on the endocrine system and on the metabolism intermediates of PLA2, normally associated with the use of these steroid drugs (Parente 2001).
5-LOX Neg (prevent) Binding (metabolism) of PLA2 in endocrine system
4) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.50 Pain Relevance 0.58

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox