INT185427

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.48
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lhx1) anatomical structure formation involved in morphogenesis (Lhx1) nucleus (Lhx1)
intracellular (Lhx1) DNA binding (Lhx1) nucleic acid binding transcription factor activity (Lhx1)
Anatomy Link Frequency
brain 1
neural 1
Lhx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 48 97.88 Very High Very High Very High
depression 74 93.12 High High
GABAergic 17 69.08 Quite High
Inflammation 48 50.00 Quite Low
Eae 4 34.00 Quite Low
gABA 28 30.00 Quite Low
Dorsal horn 5 21.76 Low Low
antidepressant 62 14.08 Low Low
Dorsal horn neuron 1 8.40 Low Low
Hippocampus 50 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Inflammatory Bowel Disease 156 99.64 Very High Very High Very High
Adhesions 13 95.00 High High
Wound Healing 6 93.48 High High
Depression 96 93.12 High High
Suicidal Behaviour 123 92.68 High High
Crohn's Disease 218 71.04 Quite High
Disease Susceptibility 5 70.28 Quite High
Stress 25 69.88 Quite High
Mental Disorders 6 69.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, members of this pathway, ROCK1 and LIM, were down-regulated in both IBD subtypes in our PCR experiments (but not in inflamed DCs), which might indicate a potential decline in cell migration and an impaired ability to maintain epithelial integrity in IBD.
Negative_regulation (regulated) of LIM associated with inflammatory bowel disease
1) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.12 Pain Relevance 0
Interestingly, members of this pathway, ROCK1 and LIM, were down-regulated in both IBD subtypes in our PCR experiments (but not in inflamed DCs), which might indicate a potential decline in cell migration and an impaired ability to maintain epithelial integrity in IBD.
Negative_regulation (down) of LIM associated with inflammatory bowel disease
2) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.12 Pain Relevance 0
Recently, it has been shown that BDNF and TrkB regulate translational machinery in dendrites.232 Moreover, BDNF induces the expression of Lim kinase 1, a protein kinase whose mRNA translation is inhibited by brain-specific microRNA-134. microRNA 134 is localized in dendrites and its overexpression leads to a decrease in spine size through repression of Lim kinase 1 mRNA translation.233 Thus, studying BDNF/TrkB and other interacting proteins in dendrites will further reveal their novel mechanistic roles in the development of depression/suicidal behavior.



Negative_regulation (repression) of Lim in brain associated with suicidal behaviour, depression and repression
3) Confidence 0.41 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.17 Pain Relevance 0.08
Knockdown of Lhx1 and Lhx5 results in decreased expression of VIAAT, although they do not appear to be obligatory determinant of inhibitory neural phenotypes and appear to play no direct role in determining GlyT2 expression (Pillai et al., 2007).
Negative_regulation (Knockdown) of Lhx1 in neural
4) Confidence 0.13 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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