INT185428

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.60
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lhx1) anatomical structure formation involved in morphogenesis (Lhx1) nucleus (Lhx1)
intracellular (Lhx1) DNA binding (Lhx1) nucleic acid binding transcription factor activity (Lhx1)
Anatomy Link Frequency
spinal cord 1
brain 1
Lhx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 50 98.32 Very High Very High Very High
Inflammation 24 96.28 Very High Very High Very High
depression 74 84.44 Quite High
GABAergic 17 74.40 Quite High
substantia gelatinosa 2 48.96 Quite Low
Eae 4 42.68 Quite Low
gABA 28 35.32 Quite Low
Dorsal horn 5 27.08 Quite Low
antidepressant 62 22.76 Low Low
Calcitonin gene-related peptide 1 14.64 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 78 99.74 Very High Very High Very High
INFLAMMATION 24 96.28 Very High Very High Very High
Suicidal Behaviour 123 94.96 High High
Depression 96 94.24 High High
Repression 2 92.00 High High
Skin Cancer 8 83.72 Quite High
Disease 40 82.12 Quite High
Disease Susceptibility 3 78.96 Quite High
Stress 25 78.56 Quite High
Mental Disorders 6 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, unlike in the IBD cohort, the expression of the remaining seven genes (CDH11, IGHG1, PP9099, TFF1, LIM, ROCK, and RCP9;Table 5) was not significantly different in between normal controls and the inflamed DC group.


Gene_expression (expression) of LIM associated with inflammatory bowel disease
1) Confidence 0.75 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.07 Pain Relevance 0.05
Recently, it has been shown that BDNF and TrkB regulate translational machinery in dendrites.232 Moreover, BDNF induces the expression of Lim kinase 1, a protein kinase whose mRNA translation is inhibited by brain-specific microRNA-134. microRNA 134 is localized in dendrites and its overexpression leads to a decrease in spine size through repression of Lim kinase 1 mRNA translation.233 Thus, studying BDNF/TrkB and other interacting proteins in dendrites will further reveal their novel mechanistic roles in the development of depression/suicidal behavior.



Gene_expression (expression) of Lim in brain associated with suicidal behaviour, depression and repression
2) Confidence 0.75 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.48 Pain Relevance 0.11
Table 2 shows that Gbx1, Lmx1b, Satb2 and Lhx1 were expressed at significantly lower levels in mutant green cells.
Gene_expression (expressed) of Lhx1
3) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Lhx1 and Lhx5 are expressed in inhibitory interneurons of the dorsal spinal cord and have been shown to increase expression of Pax2.
Gene_expression (expressed) of Lhx1 in spinal cord associated with spinal cord
4) Confidence 0.23 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

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