INT185432

Context Info Confidence 0.52 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 3.19 Pain Relevance 0.35

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD) cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)

Anatomy Link Frequency keratinocytes 1 vein 1 CYLD (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 94.64 headache 4 62.56 Inflammation 34 61.20 Inflammatory response 3 45.28 cytokine 5 5.00 depression 2 5.00 backache 2 5.00 Inflammatory mediators 2 5.00 psoriasis 2 5.00 spastic colon 1 5.00

Disease Link Frequency Relevance Heat Sick Building Syndrome 18 100.00 Skin Cancer 14 100.00 Apoptosis 25 99.64 Crohn's Disease 109 97.84 INFLAMMATION 38 94.40 Colon Cancer 7 89.88 Hepatocellular Cancer 2 89.20 Carcinoma 2 87.84 Cancer 21 80.84 Toxicity 2 80.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B, abolished the protective knockdown of apoptosis, suggesting that loss of CYLD confers resistance to apoptosis through activation of NF-?

Negative_regulation (loss) of CYLD associated with apoptosis

1) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.88 Pain Relevance 0.09

Access to the natural environment may increase individual productivity between 0.4 and 18% and reduce absenteeism, SBS, and recovery time while saving even 40% of lighting energy (Center for Building Performance and Diagnostics/Advanced Building Systems Integration Consortium 2005).

Negative_regulation (reduce) of SBS associated with sick building syndrome

2) Confidence 0.44 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892106 Disease Relevance 0.43 Pain Relevance 0.06

However, a recent report showed that the loss of CYLD in keratinocytes of mice did not affect transcription induced by the classical p65–p50 NF-?

Negative_regulation (loss) of CYLD in keratinocytes

3) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.59 Pain Relevance 0.08

International case studies demonstrate that providing individual temperature control for each worker increases individual productivity by 0.2–3% and reduces sick building syndrome (SBS) symptoms and absenteeism, while saving 25% of conditioning energy (e.g., Wyon 1996).

Negative_regulation (reduces) of SBS associated with sick building syndrome

4) Confidence 0.32 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892106 Disease Relevance 0.32 Pain Relevance 0.06

In the same vein, the marked down-regulation of CYLD is of interest as this gene has been identified as a key negative regulator of nuclear factor-kappa B (NF-?

Negative_regulation (regulation) of CYLD in vein associated with skin cancer

5) Confidence 0.20 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.96 Pain Relevance 0.06

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