INT185432

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.19
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD)
cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)
Anatomy Link Frequency
keratinocytes 1
vein 1
CYLD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 94.64 High High
headache 4 62.56 Quite High
Inflammation 34 61.20 Quite High
Inflammatory response 3 45.28 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sick Building Syndrome 18 100.00 Very High Very High Very High
Skin Cancer 14 100.00 Very High Very High Very High
Apoptosis 25 99.64 Very High Very High Very High
Crohn's Disease 109 97.84 Very High Very High Very High
INFLAMMATION 38 94.40 High High
Colon Cancer 7 89.88 High High
Hepatocellular Cancer 2 89.20 High High
Carcinoma 2 87.84 High High
Cancer 21 80.84 Quite High
Toxicity 2 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B, abolished the protective knockdown of apoptosis, suggesting that loss of CYLD confers resistance to apoptosis through activation of NF-?
Negative_regulation (loss) of CYLD associated with apoptosis
1) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.88 Pain Relevance 0.09
Access to the natural environment may increase individual productivity between 0.4 and 18% and reduce absenteeism, SBS, and recovery time while saving even 40% of lighting energy (Center for Building Performance and Diagnostics/Advanced Building Systems Integration Consortium 2005).


Negative_regulation (reduce) of SBS associated with sick building syndrome
2) Confidence 0.44 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892106 Disease Relevance 0.43 Pain Relevance 0.06
However, a recent report showed that the loss of CYLD in keratinocytes of mice did not affect transcription induced by the classical p65–p50 NF-?
Negative_regulation (loss) of CYLD in keratinocytes
3) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.59 Pain Relevance 0.08
International case studies demonstrate that providing individual temperature control for each worker increases individual productivity by 0.2–3% and reduces sick building syndrome (SBS) symptoms and absenteeism, while saving 25% of conditioning energy (e.g., Wyon 1996).


Negative_regulation (reduces) of SBS associated with sick building syndrome
4) Confidence 0.32 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892106 Disease Relevance 0.32 Pain Relevance 0.06
In the same vein, the marked down-regulation of CYLD is of interest as this gene has been identified as a key negative regulator of nuclear factor-kappa B (NF-?
Negative_regulation (regulation) of CYLD in vein associated with skin cancer
5) Confidence 0.20 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.96 Pain Relevance 0.06

General Comments

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