INT185437

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD)
cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)
Anatomy Link Frequency
skin 2
epithelium 2
CYLD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 99.28 Very High Very High Very High
cINOD 2 32.36 Quite Low
psoriasis 2 29.76 Quite Low
Inflammatory response 3 26.88 Quite Low
Inflammatory mediators 2 14.20 Low Low
cytokine 5 12.16 Low Low
colic 11 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 14 100.00 Very High Very High Very High
Crohn's Disease 109 99.96 Very High Very High Very High
Cholesteatoma 120 99.32 Very High Very High Very High
INFLAMMATION 39 99.28 Very High Very High Very High
Hypercalcemia 4 98.64 Very High Very High Very High
Hyperplasia 14 97.56 Very High Very High Very High
Inflammatory Bowel Disease 78 96.48 Very High Very High Very High
Apoptosis 25 93.32 High High
Disease 77 86.56 High High
Middle Ear Cholesteatoma 4 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the present findings suggested that downregulation of CYLD expression, which is highly expressed in normal skin, may be involved in the pathogenesis of human cholesteatoma.
Negative_regulation (downregulation) of Gene_expression (expression) of CYLD in skin associated with cholesteatoma
1) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.33 Pain Relevance 0
Therefore, investigation of CYLD expression may be a key step to understanding the cellular survival or hyperplasia in cholesteatoma epithelium.
Negative_regulation (investigation) of Gene_expression (expression) of CYLD in epithelium associated with cholesteatoma and hyperplasia
2) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.92 Pain Relevance 0
Although real-time analysis showed that this gene was also down-regulated in UC, decreased CYLD expression may represent an inflammation control response that is lost or impaired in some way in IBD.
Negative_regulation (decreased) of Gene_expression (expression) of CYLD associated with inflammatory bowel disease, crohn's disease, inflammation and skin cancer
3) Confidence 0.28 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.07 Pain Relevance 0.05
The objective of the SBS is to reduce mortality in infants and mothers, as well as the risk, duration and severity of the principal causes of morbidity and mortality in the population.
Negative_regulation (reduce) of Gene_expression (objective) of SBS
4) Confidence 0.09 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2265262 Disease Relevance 0.09 Pain Relevance 0

General Comments

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