INT185452

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 6.09
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural constituent of ribosome (CYLD) ribosome (CYLD) intracellular (CYLD)
cytoplasm (CYLD) cytosol (CYLD) peptidase activity (CYLD)
Anatomy Link Frequency
vein 1
CYLD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 106 84.80 Quite High
Inflammatory response 12 45.28 Quite Low
Calcitonin gene-related peptide 4 31.08 Quite Low
metalloproteinase 4 21.56 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
spastic colon 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 38 100.00 Very High Very High Very High
Sick Building Syndrome 10 100.00 Very High Very High Very High
Disease 161 98.56 Very High Very High Very High
Crohn's Disease 436 97.84 Very High Very High Very High
Hypercalcemia 4 97.36 Very High Very High Very High
Apoptosis 28 96.56 Very High Very High Very High
Inflammatory Bowel Disease 312 95.88 Very High Very High Very High
Cholesteatoma 120 95.16 Very High Very High Very High
Colon Disease 8 88.04 High High
INFLAMMATION 110 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the overwhelming evidence indicating the roles of CYLD and activated NF-?
Regulation (roles) of CYLD
1) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.79 Pain Relevance 0
B or CYLD are regulated according to clinical aspects, such as the presence of active otorrhea and state of bony destruction [6, 9].
Regulation (regulated) of CYLD
2) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.82 Pain Relevance 0
Recent in vitro studies on CYLD regulation have uncovered a novel autoregulatory pathway in which up-regulation of CYLD, due to activation of NF-?
Regulation (regulation) of CYLD associated with skin cancer
3) Confidence 0.29 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.96 Pain Relevance 0.04
Recent in vitro studies on CYLD regulation have uncovered a novel autoregulatory pathway in which up-regulation of CYLD, due to activation of NF-?
Regulation (regulation) of CYLD associated with skin cancer
4) Confidence 0.25 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.00 Pain Relevance 0.06
In the same vein, the marked down-regulation of CYLD is of interest as this gene has been identified as a key negative regulator of nuclear factor-kappa B (NF-?
Regulation (regulation) of CYLD in vein associated with skin cancer
5) Confidence 0.21 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.96 Pain Relevance 0.06
Eight genes (CYLD, DAF, DKFZp547A023, MUC1, OCLN, PLA2G2A, TIMP1, and ZCCHC4;Table 5) were significantly differentially regulated between normal controls and inflamed DC, and the direction of change was the same as that observed in IBD.
Regulation (regulated) of CYLD associated with inflammatory bowel disease and skin cancer
6) Confidence 0.13 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.40 Pain Relevance 0.04
The authors explain that their device has been developed for prevention and control of the “Sick Building Syndrome” (SBS).
Regulation (control) of SBS associated with sick building syndrome
7) Confidence 0.09 Published 2010 Journal Chemical Reviews Section Body Doc Link PMC2855181 Disease Relevance 0.16 Pain Relevance 0

General Comments

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