INT185482

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.76
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
macrophages 1
neurons 1
cleavage 1
fibroblasts 1
microglia 1
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 350 99.40 Very High Very High Very High
Demyelination 96 98.60 Very High Very High Very High
Inflammation 165 96.52 Very High Very High Very High
metalloproteinase 2 92.36 High High
Inflammatory response 28 91.64 High High
imagery 17 91.12 High High
qutenza 17 90.96 High High
Sciatic nerve 36 85.96 High High
Inflammatory mediators 3 85.76 High High
dorsal root ganglion 42 84.40 Quite High
Disease Link Frequency Relevance Heat
Stress Incontinence 1 99.28 Very High Very High Very High
Demyelinating Disease 99 98.60 Very High Very High Very High
INFLAMMATION 205 96.52 Very High Very High Very High
Disease 49 96.20 Very High Very High Very High
Infection 98 95.56 Very High Very High Very High
Ganglion Cysts 44 84.40 Quite High
Injury 66 82.60 Quite High
Nervous System Injury 64 81.80 Quite High
Apoptosis 22 81.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 106 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue sections were analyzed for the presence of IB4-binding neurons and either MCP-1, IP-10 or CCR2.
IP-10 Binding (binding) of in neurons
1) Confidence 0.30 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0 Pain Relevance 0
IP-10 is one of three ligands that bind to the CXCR3 receptor [34-36].
IP-10 Binding (bind) of
2) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.48 Pain Relevance 0.09
In vitro studies have shown that CXCL10 is secreted by endangered neurons and directs microglia migration by binding to the microglial CXC3 receptor.
CXCL10 Binding (binding) of in microglia
3) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.66 Pain Relevance 0.16
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
IP-10 Spec (examined) Binding (recruit) of in macrophages associated with chemokine
4) Confidence 0.18 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.60 Pain Relevance 0.56
Similarly, CXCL10, which acts through CXCR3 without prior proteolytic cleavage, induces increase in intracellular calcium and activation of caspase-3 upon binding to its receptor (Sui et al. 2004, 2006).
CXCL10 Binding (binding) of in cleavage associated with stress incontinence
5) Confidence 0.14 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.56 Pain Relevance 0.60
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
IP-10 Spec (examined) Binding (recruit) of in fibroblasts associated with chemokine
6) Confidence 0.06 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.60 Pain Relevance 0.56
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
IP-10 Spec (examined) Binding (recruit) of in mastocytes associated with chemokine
7) Confidence 0.06 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.60 Pain Relevance 0.56
IP-10, the ligand for the CXCR3 chemokine receptor, was not upregulated in this animal model (data not shown).
IP-10 Binding (ligand) of associated with chemokine
8) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.25 Pain Relevance 0.60

General Comments

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