INT185484

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.44
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
microglia 4
neuron 3
pore 2
hippocampus 2
astrocytes 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 190 100.00 Very High Very High Very High
Hippocampus 54 99.84 Very High Very High Very High
ischemia 38 99.68 Very High Very High Very High
agonist 51 99.06 Very High Very High Very High
dorsal root ganglion 5 98.56 Very High Very High Very High
Potency 93 98.28 Very High Very High Very High
Arthritis 10 97.36 Very High Very High Very High
Glutamate 54 97.28 Very High Very High Very High
Eae 19 97.04 Very High Very High Very High
Inflammation 95 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 34 99.68 Very High Very High Very High
Ganglion Cysts 5 98.56 Very High Very High Very High
Injury 76 98.44 Very High Very High Very High
Arthritis 8 97.36 Very High Very High Very High
Inflammatory Pain 20 97.04 Very High Very High Very High
Death 25 96.52 Very High Very High Very High
Epilepsy 16 96.40 Very High Very High Very High
INFLAMMATION 107 96.24 Very High Very High Very High
Nociception 26 95.60 Very High Very High Very High
Neuropathic Pain 100 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent data indicate that, in response to ATP binding, the P2X7 receptors facilitate cation channel activation, non-specific pore formation, rapid changes in plasma membrane morphology (blebbing) and secretion of IL-1?
Positive_regulation (facilitate) of Gene_expression (receptors) of P2X7 in pore
1) Confidence 0.31 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.26 Pain Relevance 0.38
In addition, a recent study has shown that activation of P2X7 receptors expressed on satellite glia that enwrap each DRG neuron leads to a release of TNF-?
Positive_regulation (activation) of Gene_expression (expressed) of P2X7 in neuron associated with dorsal root ganglion
2) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.36 Pain Relevance 0.82
Collectively, the foregoing results illustrate the potential role of the P2X7 receptor in modulating IL-1?
Positive_regulation (role) of Gene_expression (receptor) of P2X7
3) Confidence 0.25 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.89 Pain Relevance 0.69
Fig. 6Cyanoguanidine-piperazine P2X7 antagonists

Aryltetrazoles/aryltriazoles

Positive_regulation (piperazine) of Gene_expression (antagonists) of P2X7 associated with antagonist
4) Confidence 0.22 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.32
Fig. 7Aryltetrazole and aryltriazole P2X7 antagonists
Positive_regulation (aryltriazole) of Gene_expression (antagonists) of P2X7 associated with antagonist
5) Confidence 0.22 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.26
In our study, immunocytochemistry showed expression of P2X7 and active caspase 3 at GSA-positive cells after injury without agonist application.
Positive_regulation (active) of Gene_expression (expression) of P2X7 associated with injury and agonist
6) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.75 Pain Relevance 0.15
Treatment with the GABAB receptor agonist baclofen and antagonist phaclofen resulted in increased and decreased P2X7 receptor expression in hippocampus, respectively [140].
Positive_regulation (increased) of Gene_expression (expression) of P2X7 receptor in hippocampus associated with antagonist, agonist and hippocampus
7) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.70 Pain Relevance 0.57
Increased P2X7 receptor expression in astrocytes, microglia, and neurons appears to contribute to the mechanisms of cell death caused by in vivo and in vitro ischemia [162, 163].
Positive_regulation (Increased) of Gene_expression (expression) of P2X7 receptor in microglia associated with ischemia and death
8) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.16 Pain Relevance 0.36
Increased P2X7 receptor expression in astrocytes, microglia, and neurons appears to contribute to the mechanisms of cell death caused by in vivo and in vitro ischemia [162, 163].
Positive_regulation (Increased) of in astrocytes Gene_expression (expression) of P2X7 receptor in microglia associated with ischemia and death
9) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.16 Pain Relevance 0.36
Increased P2X7 receptor expression in astrocytes, microglia, and neurons appears to contribute to the mechanisms of cell death caused by in vivo and in vitro ischemia [162, 163].
Positive_regulation (Increased) of in neurons Gene_expression (expression) of P2X7 receptor in microglia associated with ischemia and death
10) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.16 Pain Relevance 0.36

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