INT185485

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
endothelial cells 3
nerves 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 44 97.16 Very High Very High Very High
Inflammation 82 94.40 High High
Antinociceptive 22 51.12 Quite High
Antihyperalgesic 20 50.00 Quite Low
IPN 16 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 16 5.00 Very Low Very Low Very Low
withdrawal 14 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
diclofenac 12 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 94.40 High High
Hyperalgesia 24 5.00 Very Low Very Low Very Low
Inflammatory Pain 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Relapsing Polychondritis 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that oATP, by blocking the P2X7 receptors present on nerves and endothelial cells, could regulate some effects of ATP (having pronociceptive functions when released) on these structures.
Negative_regulation (blocking) of Localization (present) of P2X7 in endothelial cells
1) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.31
We hypothesize that oATP, by blocking the P2X7 receptors present on nerves and endothelial cells, could regulate some effects of ATP (having pronociceptive functions when released) on these structures.
Negative_regulation (blocking) of in nerves Localization (present) of P2X7 in endothelial cells
2) Confidence 0.09 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.47 Pain Relevance 0.31

General Comments

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