INT185487

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.21
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
microglia 2
neurons 1
vessels 1
vesicles 1
spinal cord dorsal horn 1
Cxcl10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 356 100.00 Very High Very High Very High
metalloproteinase 4 100.00 Very High Very High Very High
Peripheral nervous system 3 99.46 Very High Very High Very High
Pain 59 98.24 Very High Very High Very High
Spinal cord 23 97.88 Very High Very High Very High
Dorsal horn 6 97.40 Very High Very High Very High
nociceptor 18 96.52 Very High Very High Very High
c fibre 12 96.04 Very High Very High Very High
glial activation 8 95.48 Very High Very High Very High
Demyelination 141 91.84 High High
Disease Link Frequency Relevance Heat
Disease 69 99.94 Very High Very High Very High
Injury 48 99.72 Very High Very High Very High
Pain 92 98.24 Very High Very High Very High
Infection 120 98.00 Very High Very High Very High
Demyelinating Disease 144 91.84 High High
INFLAMMATION 153 89.68 High High
Nervous System Injury 84 87.68 High High
Neuropathic Pain 53 79.56 Quite High
Apoptosis 40 76.40 Quite High
Hypersensitivity 14 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Localization (released) of IP10 in vesicles associated with chemokine
1) Confidence 0.61 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
Following strong neuronal excitation in the peripheral nervous system (i.e. trauma or disease), IP-10 may be released within the DRG and/or from central terminals in the spinal cord dorsal horn resulting in both local and distant glial activation [26,56,57].
Localization (released) of IP-10 in spinal cord dorsal horn associated with peripheral nervous system, injury, dorsal horn, disease, glial activation and spinal cord
2) Confidence 0.57 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.48 Pain Relevance 0.61
This differs from the case of IP-10, where a majority of the neurons upregulating this chemokine did not co-localize with IB-4.
Localization (localize) of IP-10 in neurons associated with chemokine
3) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.77 Pain Relevance 1.10
In vitro studies have shown that CXCL10 is secreted by endangered neurons and directs microglia migration by binding to the microglial CXC3 receptor.
Localization (secreted) of CXCL10 in microglia
4) Confidence 0.42 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.63 Pain Relevance 0.15
Our data show that concomitantly with the up-regulation of the microglia associated transcripts (CD68 and AIF-1), the released "On" signals matrix-metalloproteinase-3 (MMP-3) and CXCL10 are up-regulated in the acute phase (1 day after infection) of the disease, whereas the released "Off" signal CX3CL1 is down-regulated.
Localization (released) of CXCL10 in microglia associated with metalloproteinase, disease and infection
5) Confidence 0.37 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.47 Pain Relevance 0.12
IP-10 and IL-8 were co-localized on the wall of small vessels in carrageenan-inflamed paws of intraplantarly oATP-treated rats.
Localization (localized) of IP-10 in vessels
6) Confidence 0.35 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.29 Pain Relevance 0.29
The IP-10 appeared co-localized with IL-8 on small vessel wall of dermis reticular layer in specimens from rat paws carrageenan-injected, then submitted to oATP local treatment (Fig. 6c).
Localization (localized) of IP-10 in dermis reticular layer
7) Confidence 0.30 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.29 Pain Relevance 0.35

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