INT185490

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Atp5o) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
nerves 3
vessels 1
Atp5o (Rattus norvegicus)
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 82 100.00 Very High Very High Very High
chemokine 44 89.76 High High
Antihyperalgesic 20 50.00 Quite Low
Antinociceptive 22 31.68 Quite Low
Inflammatory response 8 12.64 Low Low
IPN 16 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 16 5.00 Very Low Very Low Very Low
withdrawal 14 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
diclofenac 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 100.00 Very High Very High Very High
Hyperalgesia 24 5.00 Very Low Very Low Very Low
Inflammatory Pain 16 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Relapsing Polychondritis 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, oATP could block such amplifying mechanism of inflammation and also downregulate P2X7 receptor expression, especially in vessels and nerves close to the site of inflammation (see Fig 4).
oATP Negative_regulation (downregulate) of Gene_expression (expression) of P2X7 receptor in nerves associated with inflammation
1) Confidence 0.01 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.44 Pain Relevance 0.26
Indeed, oATP could block such amplifying mechanism of inflammation and also downregulate P2X7 receptor expression, especially in vessels and nerves close to the site of inflammation (see Fig 4).
oATP Negative_regulation (downregulate) of in vessels Gene_expression (expression) of P2X7 receptor in nerves associated with inflammation
2) Confidence 0.00 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.44 Pain Relevance 0.26

General Comments

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